Urinary phenylpyruvate (PA)

Due to the deficiency or deficiency of phenylalanine hydroxylase in patients, phenylalanine cannot be converted to tyrosine in metabolism, and phenylalanine is produced by transaminase to form phenylpyruvate from urine. A large amount of phenylpyruvate accumulates in the body, which can damage the nervous system of the patient and affect the pigment metabolism in the body. The phenylpyruvate assay is commonly used in the screening of neonatal phenylketonuria (PKU), which causes congenital dementia in newborns. This test is only a PKU screening test, if necessary, serum phenylalanine content determination, usually when the serum phenylalanine up to 1.2mmol / L (20mg / dl) or more, the diagnosis can be confirmed. Basic Information Specialist classification: growth and development check classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Found in phenylketonuria (PKU). Tips: Should be checked within 30 to 60 days of birth. Need to take fresh urine, do not take phenolic drugs before the experiment. Normal value Qualitative negative. Recorded as (-). Clinical significance Positive for phenylketonuria (PKU). Positive result may be disease: phenylketonuria precautions Should be checked within 30 to 60 days of birth. Need to take fresh urine, do not take phenolic drugs before the experiment. Inspection process (1) 4 ml of urine plus 1 ml of precipitant, mix, stand for a while, remove the precipitate by filter paper or centrifugation to obtain clear urine. (2) Clarify 2 to 3 drops of urinary concentrated hydrochloric acid, 2 to 3 drops of ferric chloride solution, add 1 drop each, mix well, and observe the result immediately. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Nothing.