Urinary galactose

Congenital galactosemia is an autosomal recessive disorder. Due to the lack of galactose-1-phosphate uridine invertase or galactose kinase, it is not possible to convert galactose into glucose. The child may have liver enlargement, liver function damage, growth and development stagnation, mental retardation, and restlessness after breastfeeding. , antifeeding, vomiting, diarrhea, renal tubular dysfunction, etc., in addition to amino acid urine (fine, silk, glycine, etc.). Galactoseuria can also occur in cataract patients caused by galactosidase deficiency. Basic Information Specialist classification: growth and development check classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: No relevant information. Normal value: Urinary galactose: 41-116μmol/24h Above normal: Increased congenital lactose intolerance can be seen in lactating women. negative: Positive: Tips: The measurement should be compared with the standard color plate according to the specified time, otherwise the result will be affected. Urine specimens should be fresh to avoid sugar breakdown or urine pH changes. Vitamin C, cephalosporin and other drugs can be false negative. The test paper may be ineffective under moisture and should not be exposed to air or sunlight. It should be stored in a sealed manner. Normal value 41 to 116 μmol / 24 h (14 to 40 mg / 2 h). Clinical significance Increased congenital lactose intolerance can be seen in lactating women. High results may be diseases: galactosemia considerations (1) This method is an enzymatic reaction with higher sensitivity and specificity than the Zebra method. The measurement should be compared with the standard color plate according to the specified time, otherwise the result will be affected. (2) Urine specimens should be fresh to avoid sugar breakdown or urine pH changes. Vitamin C, cephalosporin and other drugs can be false negative. (3) The test paper may be ineffective due to moisture, and shall not be exposed to air and sunlight, and should be sealed and stored. Inspection process Urinary galactose in body fluids is enzymatically reacted by glucose oxidase to produce glucose and urinary acid and H2O2. The latter produces a new ecological oxygen through the action of an oxide enzyme, and the colorless reduced 4-aminoantipyrine is coupled with a phenol to be oxidized to a red quinoid compound. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Nothing.