cerebrospinal fluid free myelin basic protein antibody

MBP is synthesized in oligodendrocytes. It consists of 170 amino acid residues with a molecular weight of 18,000 and is rich in lipids. The protein content is about 30%, and MBP is a component of nerve tissue. In the worsening type of multiple sclerosis, the following FMBP is the main cause of elevated CSF, and stable multiple sclerosis is mainly caused by elevated BMBP. The former has an increased ratio of FMBP/BMBP and the latter decreases. Basic Information Specialist classification: examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Tips: After taking CSF, centrifuge the supernatant for determination, or set the supernatant to 4 °C for no more than 72 days, -20 °C for 6 months, and -70 °C for long-term storage. Normal value 0.25 to 2.87 μg / L. Clinical significance Multiple sclerosis, optic neuromyelitis, sporadic encephalitis, tuberculous spinal arachnoiditis, brain tumor, spinal cord tumor, hydrocephalus, cranial surgery, infectious polyradiculitis, subacute combined degeneration, cerebral thrombosis The amount of antibodies in CSF, such as cerebral hemorrhage and pre-senile dementia, is elevated. The worsening type of multiple sclerosis is mainly caused by the increase of FMBP and FMBPA, and the ratio of FMBP/BMBP is increased; the stable type is dominated by the increase of BMBP and BMBPA, and the ratio of FMBP/BMBP is decreased. High results may be diseases: sporadic encephalitis, subacute sclerosing panencephalitis, multiple sclerosis, metachromatic leukodystrophy, hypoxic ischemic encephalopathy After taking CSF, the supernatant is centrifuged for measurement, or the supernatant is set at 4 ° C for no more than 72 days, -20 ° C for 6 months, and -70 ° C for long-term storage. Inspection process An ELISA procedure was used. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.