cerebrospinal fluid glucose

The amount of glucose in the cerebrospinal fluid depends on several factors: 1 the concentration of blood glucose; 2 the permeability of the blood-brain barrier; 3 the degree of glycolysis in the cerebrospinal fluid; 4 the function of carrying the operating system. With a quantitative assay of glucose oxidase or hexokinase, if the specimen is to be stored for a long period of time, an appropriate amount of sodium fluoride may be added to inhibit the utilization of glucose by cells or bacteria. Basic Information Specialist classification: examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Mild or moderate reduction of syphilis and meningeal multiple malignant tumor metastasis. Significantly reduce meningitis (bacterial, tuberculous, Cryptococcus neoformans). Normal value: Cerebrospinal fluid glucose (infant): 3.9-5.0mmol/L Cerebrospinal fluid glucose (child): 2.8-4.5mmol/L Cerebrospinal fluid glucose (usually?6-4.5mmol/L Above normal: Mainly found in nervous system infectious diseases, including: 1 purulent meningitis, can be reduced to below 1.11mmol / L 24h after onset, even in the event of high tide, no sugar can exist; 2 tuberculous meningitis, the initial stage of the disease may be slightly increased or Normal, later gradually reduced, at the lowest can be reduced to below 0.83mmol / L; 3 fungal and amoebic meningitis and some mumps complicated with meningitis; 4 in addition to brain parasitic diseases and malignant tumors such as Brain tumors, melanoma metastases, etc. Patients with hypoglycemia also showed a decrease in CSF glucose levels. negative: Positive: Reminder: The examinee should stop taking all medications and maintain a reasonable diet and routine. Normal value Baby 3.9 ~ 5.0mmol / L; Children 2.8 ~ 4.5mmol / L; Adults 3.6 ~ 4.5mmol / L. Clinical significance Abnormal result Mild or moderate reduction Syphilis, meningeal multiple malignant tumor metastasis. Significantly reduced Meningitis (bacterial, tuberculous, Cryptococcus neoformans). People who need to be tested People with stiff neck, severe headache, loss of appetite, unconsciousness, vomiting, convulsions, burnout, sleepiness, sensitivity to light, small blood spots on the skin, and skin rash. Low results may be diseases: high cryptococcal meningitis results may be high disease: arachnoiditis, bacterial meningitis, neurosyphilis precautions Before the test: the examinee should stop taking all the drugs and maintain a reasonable diet and work schedule. When checking: Eliminate the anxiety and anxiety. Inspection process 1. The patient lies on the hard board bed, the back is perpendicular to the table top, the head is bent as far as possible to the chest, the knees are tightly attached to the abdomen with both hands, so that the trunk is as arched as possible; or the assistant is used to hold the patient's head opposite the surgeon. The other hand pulls the lower limbs of the armpits and holds them tightly, so that the spine is as convex as possible to widen the intervertebral space, which is convenient for needle insertion. 2, determine the puncture point, usually the junction point of the highest point of the bilateral iliac spine and the posterior median line as the puncture point, here is equivalent to the third to fourth lumbar spine process, sometimes in the upper or lower lumbar spine The gap is carried out. 3, routine disinfection of the skin after wearing sterile gloves, cover the hole towel, with 2% lidocaine from the skin to the interspinous ligament for layer-by-layer local anesthesia. 4, the surgeon uses the left hand to fix the puncture point skin, the right hand holding puncture needle to the vertical back, the needle tip slightly obliquely to the direction of the head, the adult needle depth is about 4 ~ 6cm, children about 2 ~ 4cm. When the needle passes through the ligament and the dura mater, there is a sudden loss of resistance. At this point, the needle core can be slowly withdrawn (to prevent the cerebrospinal fluid from flowing out quickly, causing cerebral palsy), and the cerebrospinal fluid can be seen to flow out. 5. Connect the pressure measuring tube to measure the pressure before draining. The cerebrospinal fluid pressure in the normal lateral position is 70-180 mmH2O (0.098 Kpa=10 mmH2O) or 40-50 d/min. If you continue to do the queckstedt test, you can see if there is any obstruction in the subarachnoid space. That is, after the initial pressure is measured, the assistant first compresses one side of the carotid artery for about 10 s, then presses the other side, and finally presses both sides of the carotid artery. When the carotid artery is compressed at normal time, the pressure of the cerebrospinal fluid immediately increases by about one time, and after 10 to 20 seconds after the pressure is released, it rapidly drops to the original level, which is called negative in the obstruction test, indicating that the subarachnoid space is unobstructed; if the carotid artery is compressed, it cannot be When the pressure of the cerebrospinal fluid is raised, the obstruction test is positive, indicating that the subarachnoid space is completely blocked. If it rises slowly after applying pressure, it will slowly fall after relaxation, indicating incomplete obstruction. but. Those with increased intracranial pressure are forbidden to do this test. 6. Remove the pressure measuring tube and collect 2~5ml of cerebrospinal fluid for examination. If it is needed for cultivation, use sterile tube to keep the specimen. 7. After the operation, insert the needle core and pull out the puncture needle together, cover the sterile gauze, and fix it with tape. 8, go to the pillow for 4 to 6 hours, so as not to cause postoperative low intracranial pressure headache. With a quantitative assay of glucose oxidase or hexokinase, if the specimen is to be stored for a long period of time, an appropriate amount of sodium fluoride may be added to inhibit the utilization of glucose by cells or bacteria. Not suitable for the crowd Before the test: the examinee should stop taking all the drugs and maintain a reasonable diet and work schedule. When checking: Eliminate the anxiety and anxiety. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.