CSF colloidal gold test

The colloidal gold test method is a special test method used in clinical diagnosis and differential diagnosis. This test lacks specificity and cannot specifically diagnose the disease. It has not helped much for treatment diagnosis and has been phased out. The protein content in normal cerebrospinal fluid is very small, and it is mostly albumin, which cannot cause precipitation and color change of colloidal gold solution. When there is a neurological disease that causes changes in cerebrospinal fluid protein, especially when the globulin is increased, it can react with the colloidal gold solution to cause precipitation and color change (rose red, purple, blue). Basic Information Specialist classification: examination classification: cerebrospinal fluid examination Applicable gender: whether men and women are applicable for fasting: Tips: The examinee should suspend taking the drug. Normal value 0001111000 (symbol representation; 0 is rose red is the same as the control tube, 1 is reddish blue, 2 is lavender or purple, 3 is blue, 4 is micro blue, 5 is colorless). Clinical significance Abnormal result (1) Syphilis type 0123320000 or 0134321000, found in various types of brain syphilis, multiple sclerosis. (2) paralyzed 5555542100 or 5554321000, seen in paralytic dementia, spinal cord spasm, multiple sclerosis. (3) meningitis type 0001224531 or 0011232210, found in various cocciic meningitis, tuberculous meningitis. (The symbol represents; 0 is rose red is the same as the control tube, 1 is reddish blue, 2 is lavender or purple, 3 is blue, 4 is bluish, and 5 is colorless). People who need to be tested People with temperament, mild fever, headache, no cause of vomiting, intractable constipation or lethargy and annoyance. Precautions Before testing: The examinee should suspend taking the drug. At the time of testing: the examinee will have some discomfort, but it is necessary to eliminate the anxiety and anxiety. Not suitable for the crowd: no. Inspection process The protein content in normal cerebrospinal fluid is very small, and it is mostly albumin, which cannot cause precipitation and color change of colloidal gold solution. When there is a neurological disease that causes changes in cerebrospinal fluid protein, especially when the globulin is increased, it can react with the colloidal gold solution to cause precipitation and color change (rose red, purple, blue). When the test is done, the cerebrospinal fluid is diluted differently. According to the law of color change caused by different dilutions, the disease can be divided into sputum, syphilis and meningitis. The exact composition and content of the color change caused by this test are still unclear, and there is no objective index for judging the color change, which is difficult to grasp. In addition, there are many interference factors in the test, and the results vary greatly, and the operation is troublesome. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.