Cerebrospinal fluid protein characterization (CSF.Pro)

Under normal circumstances, the protein content in the cerebrospinal fluid is much lower than that in the blood. When there is inflammation in the meninges, brain or spinal cord, the protein content in the cerebrospinal fluid is increased, and the increase is mostly globulin. Cerebrospinal fluid protein test is positive, common in brain tissue and meningitis. Such as purulent meningitis (3 ~ 6.5g / L), tuberculous meningitis (0.3 ~ 2.09g / L), syphilitic central nervous system diseases, poliomyelitis, epidemic encephalitis. Basic Information Specialist classification: examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Found in the brain, spinal cord and meningeal inflammation, tumors, hemorrhage, etc., as well as brain softening, spinal cord tumors, degenerative brain diseases, radiculopathy, cerebrospinal fluid circulation obstruction and other diseases. Tips: Use aspirin, chlorpromazine, salicylate, penicillin, sulfonamides and other drugs, can interfere with protein qualitative test. Normal value Pan's method is negative or weakly positive. Clinical significance Cerebrospinal fluid protein assays reflect changes in the central nervous system. Positive is common in brain, spinal cord and meningeal inflammation, tumors, hemorrhage, etc., as well as brain softening, brain degenerative diseases, radiculopathy, cerebrospinal fluid circulation obstruction and other diseases. Drugs such as aspirin, chlorpromazine, salicylate, penicillin, and sulfonamide can interfere with the test. Positive results may be diseases: meningitis, tropical spastic paraplegia considerations (1) Pan's method is highly sensitive; Luo Qiong method is mainly sensitive to globulin and has high specificity. Once the test is positive, the diagnostic value is large. (2) The use of aspirin, chlorpromazine, salicylate, penicillin, sulfonamides and other drugs can interfere with protein qualitative tests. Inspection process Pipette 2 ml of 5% carbolic acid solution in a small test tube, add 1 drop of cerebrospinal fluid, and see the presence of white cloud and turbidity on the black background with the sinking of cerebrospinal fluid. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.