cerebrospinal fluid cholinesterase

There are two classes of cholinesterases, namely acetylcholinesterase (AchE, specificity) and cholinesterase (PchE, non-specific) AchE hydrolyzing the central nervous system and parasympathetic ganglia fibers and autonomic ganglia fiber impulses. The release of acetylcholine ensures the coordination of nerve excitation and inhibition; in addition to hydrolyzing acetylcholine, PchE may also hydrolyze other choline esters, and may even regulate the metabolism of physiological or pharmacologically active substances. Basic Information Specialist classification: examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Can be seen in hereditary serum CHE abnormalities, hunger, infection and anemia. Normal value: Cerebrospinal fluid cholinesterase: 0.5-1.3U Above normal: Seen when the blood-brain barrier is destroyed. PchE increased in head trauma, meningitis, and polio, while AchE activity decreased. AchE is significantly elevated in multiple sclerosis, and can also be increased in diffuse sclerosis, myasthenia gravis, malignant brain tumors, brain contusion, and Guillain-Barré syndrome. negative: Positive: Tips: The determination of CHE in cerebrospinal fluid can reflect the infection of the central nervous system. Normal value 0.5 to 1.3 U. Clinical significance When the blood-brain barrier is destroyed, PchE and AchE activity is increased; PchE is increased in head trauma, meningitis, polio, and AchE activity is decreased. AchE is significantly elevated in multiple sclerosis, and can also be increased in diffuse sclerosis, myasthenia gravis, malignant brain tumors, brain contusion, and Guillain-Barré syndrome. CHE reduction can also be seen in hereditary serum CHE abnormalities, hunger, infection and anemia. Low results may be diseases: high anemia results may be diseases: myasthenia gravis, meningitis, multiple sclerosis considerations CHE reduction can also be seen in hereditary serum CHE abnormalities, hunger, infection and anemia. Inspection process Use the colorimetric method. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.