Glucagon challenge test

The glucagon test refers to injecting glucagon into a patient and observing the high blood glucose level in the patient to determine the disease. In normal healthy people and those with essential hypertension, blood pressure does not rise or decrease after injection of glucagon. In patients with pheochromocytoma, about 15 seconds after intravenous administration of glucagon, the blood pressure rises sharply, often exceeding 26.6/21.3 kPa (200/160 mmHg), and the pressure-increasing reaction is higher than the highest blood pressure in the cold-pressure test by 2.7/1.3 kPa or more. . Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: After 8 pm on the day before the medical examination, you should fast. Normal value In normal healthy people and those with essential hypertension, blood pressure does not rise or decrease after injection of glucagon. Clinical significance In patients with pheochromocytoma, about 15 seconds after intravenous administration of glucagon, the blood pressure rises sharply, often exceeding 26.6/21.3 kPa (200/160 mmHg), and the pressure-increasing reaction is higher than the highest blood pressure in the cold-pressure test by 2.7/1.3 kPa or more. . High results may be diseases: pediatric glycogen storage disease type I, pheochromocytoma, pediatric glycogen storage disease type IV, hypoglycemia syndrome precautions First, the precautions before blood draw 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the physical examination, fasting should be done to avoid affecting the detection of indicators such as blood glucose in the second sky. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection; guests with a history of fainting, please explain in advance, we will make special arrangements; Second, should pay attention after blood draw 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process Because of the use of glucagon, its side effects are much smaller than histamine, and the risk is also small. The dose of the drug is 0.5 to 1 mg intravenously. After 2 minutes, the blood pressure exceeds the cold compression test level or increases by 8/5.3 kpa (60/40 mmHg). ), and maintain positive for more than 5min. Not suitable for the crowd People with reduced hematopoietic function such as leukemia, various anemia, myelodysplastic syndrome, or people with thrombocytopenia should pay attention to blood draw, and should not take more or more blood. Adverse reactions and risks 1. After the blood is drawn, do not press the needle hole to avoid subcutaneous hematoma. If there is a small piece of bruise in the blood, it is slightly tender, please don't panic, you can do hot compress after 24 hours to promote the absorption of blood. The general small amount of congestion will gradually absorb in 3 to 5 days and the color will become lighter and return to normal. 2. After the blood draw, symptoms such as dizziness, vertigo, fatigue, etc. should be immediately supine, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.