plasma aldosterone

Plasma aldosterone (Ald) is an important mineralocorticoid secreted by the adrenal cortical globular band and has a physiological role in regulating sodium and potassium metabolism and extracellular fluid capacity. Ald is mainly regulated by the renin-angiotensin system, and the levels of sodium and potassium in the body, ACTH, adrenal and dopaminergic systems, and blood volume all regulate the secretion of aldosterone. Ald is present in free form in 30% to 40% of the blood circulation, and approximately 6% of unmetabolized aldosterone is excreted from the urine. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Anterior pituitary hypofunction, adrenal insufficiency, aldosterone levels were significantly reduced. In the former, the level of ACTH in the blood decreased, and the latter increased in ACTH. Selective low aldosteronism occurs due to kidney deficiency of renin, which results in low renin and low aldosteronism. Inadequate water intake or insufficient potassium intake, as well as the use of reserpine, propranolol and other drugs can cause aldosterone reduction. Normal value: Plasma aldosterone (recumbent position): 1ng/dL-5ng/dLng/dL Plasma aldosterone (position): 5 ng / dL - 15 ng / dLng / dL Above normal: Because of adrenal hyperplasia, adenoma or cancer, it can cause excessive aldosterone secretion, called primary aldosteronism; congestive heart failure, cirrhosis ascites, nephrotic syndrome, special edema, renal artery stenosis or ischemia And the loss of salty kidney disease or intestinal disease can cause an increase in plasma aldosterone, called secondary aldosteronism. Aldosterone can also be increased during pregnancy, excessive sweating, and the use of female contraceptives and estrogens. negative: Positive: Tips: taking certain drugs can affect the results of aldosterone determination, such as oral contraceptives, estrogens, furosemide, angiotensin and other drugs can make the test results higher; taking risperidone, dehydrocorticosterone, propranolone Lol, methyldopa and the use of heparin can reduce the measurement results. Normal value Plasma lying position 1 ~ 5ng / dL; Standing position 5 ~ 15ng / dL. Clinical significance (1) due to adrenal hyperplasia, adenoma or cancer can cause excessive aldosterone secretion, called primary aldosteronism; congestive heart failure, cirrhosis ascites, nephrotic syndrome, special edema, renal artery stenosis Or ischemia and salt-losing nephropathy or intestinal diseases can cause an increase in plasma aldosterone, called secondary aldosteronism. Aldosterone can also be increased during pregnancy, excessive sweating, and the use of female contraceptives and estrogens. (2) anterior pituitary hypofunction, adrenal insufficiency aldosterone levels were significantly reduced. In the former, the level of ACTH in the blood decreased, and the latter increased in ACTH. Selective low aldosteronism occurs due to kidney deficiency of renin, which results in low renin and low aldosteronism. Inadequate water intake or insufficient potassium intake, as well as the use of reserpine, propranolol and other drugs can cause aldosterone reduction. High results may be diseases: pediatric hyperaldosteronism, endocrine hypertension, lider syndrome, Gordon syndrome, primary aldosteronism considerations (1) Specimens are kept with serum cortisol. However, the diet should control sodium and potassium. The standard diet is: sodium 100mmol/d and potassium 60-100mmol/d. (2) taking certain drugs can affect the results of aldosterone determination, such as oral contraceptives, estrogens, furosemide, angiotensin and other drugs can make the test results higher; taking risperidone, dehydrocorticosterone, propranolone Lol, methyldopa and the use of heparin can reduce the measurement results. (3) Diets that limit sodium and potassium can make the measurement results high. Inspection process Radioimmunoassay. Not suitable for the crowd People with reduced hematopoietic function such as leukemia, various anemia, myelodysplastic syndrome, or people with thrombocytopenia should pay attention to blood draw, and should not take more or more blood. Adverse reactions and risks 1. After the blood is drawn, do not press the needle hole to avoid subcutaneous hematoma. If there is a small piece of bruise in the blood, it is slightly tender, please don't panic, you can do hot compress after 24 hours to promote the absorption of blood. The general small amount of congestion will gradually absorb in 3 to 5 days and the color will become lighter and return to normal. 2. After the blood draw, symptoms such as dizziness, vertigo, fatigue, etc. should be immediately supine, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.