Human chorionic gonadotropin (HCG)

Human chorionic gonadotropin is a glycoprotein secreted by the trophoblast cells of the placenta, which is composed of glycoproteins of alpha and beta dimers. Human chorionic gonadotropin (HCG) alpha beta, synthesized by syncytiotrophoblasts. The glycoprotein hormone with a molecular weight of 36700, the alpha subunit is similar to the FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary, so that they can cross-react with each other, while the β-subunit The structure of the base is not similar. β-HCG is similar in structure to β-LH, but the last 24 amino acid extensions are absent in β-LH. Basic Information Specialist classification: gynecological examination classification: endocrine examination Applicable gender: whether women are fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Pregnancy or other malignant disease. Tips: If the first 6 to 8 weeks of pregnancy, serum β human chorionic gonadotropin can not continue to increase at a rate of 66% per day, should consider the possibility of threatened abortion or ectopic pregnancy. Normal value Test tube method (urine or serum) is negative. Negative radioreceptor method. (β-subunit) No men. Female pregnancy 7 to 10 days > 5.0 U / L (> 5.0 mU / ml). 30 days of pregnancy > 100 U / L (> 100 mU / ml). 40 days of pregnancy> 2000 U / L (> 2000 mU / ml). 50 to 100 KU / L (50 ~ 100 U / ml) for 10 weeks of pregnancy. 10 to 20 KU/L (10 to 20 U/ml) at 14 weeks of gestation. Trophoblastic cell disease >100 KU / L (> 100 U / ml). Clinical significance Increased in normal pregnancy, early pregnancy, choriocarcinoma, hydatidiform mole, ectopic pregnancy, cervical cancer, ovarian cancer, testicular tumor, stomach cancer, liver cancer, pancreatic cancer, breast cancer, pregnancy toxemia. Reduced in the threatened abortion and so on. Positive results may be diseases: choriocarcinoma, pediatric Down's syndrome, hydatidiform mole, pediatric pineal region tumor, adolescent and pediatric ovarian tumor, testicular feminization, tubal pregnancy, persistent tubal pregnancy, tubal pregnancy rupture, erosive grapes Fetal precautions For the first 6 to 8 weeks of pregnancy, serum beta human chorionic gonadotropin cannot continue to increase at a rate of 66% per day. The possibility of threatened abortion or ectopic pregnancy should be considered. Inspection process (1) Take the test tube number, wherein: the NSB tube is used for the non-specific binding rate of the assay method. The B0 tube was used to determine the specific binding rate of zero standard. B1 to 5 tubes were used to determine the specific binding rate of each standard. The S tube is used to determine the binding rate of the blood sample to be tested. (3) Take 3 tubes to measure the total radioactivity, which is worth (T). (4) Place at room temperature (>20 ° C) for 15 min (or 37 ° C warm bath for 15 min). (5) Centrifuge at 2000 × g for 15 min, and discard the supernatant. (6) Measure the background BG and the radioactivity of each tube. The measurement time is the optimal counting time with the T tube count greater than 10.000, and the double tube results take the average value. Not suitable for the crowd People with reduced hematopoietic function such as leukemia, various anemia, myelodysplastic syndrome, or people with thrombocytopenia should pay attention to blood draw, and should not take more or more blood. Adverse reactions and risks 1. After the blood is drawn, do not press the needle hole to avoid subcutaneous hematoma. If there is a small piece of bruise in the blood, it is slightly tender, please don't panic, you can do hot compress after 24 hours to promote the absorption of blood. The general small amount of congestion will gradually absorb in 3 to 5 days and the color will become lighter and return to normal. 2. After the blood draw, symptoms such as dizziness, vertigo, fatigue, etc. should be immediately supine, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.