Hepatitis B two and a half

Two and a half pairs of hepatitis B are the most commonly used serum markers for hepatitis B virus (HBV) infection detection in domestic hospitals. Hepatitis B virus immunological markers are a total of 3 pairs, namely surface antigen (HBsAg) and surface antibodies (anti-HBs or HBsAb), e antigen (HBeAg) and e antibodies (anti-HBe or HBeAb), core antigen (HBcAg) and core antibodies (anti-HBc or HBcAb). Two pairs of hepatitis B are also called five items of hepatitis B. The significance of the examination is to check whether the specific conditions of hepatitis B infection and infection are different, and distinguish the big three yang and the small three yang. Basic Information Specialist classification: Infectious disease examination and classification: blood examination Applicable gender: whether men and women apply fasting: fasting Included items: Hepatitis B antigen antibody detection, Hepatitis B virus surface antigen (HBsAg), Hepatitis B virus surface antibody (HBsAb), Hepatitis B virus e antigen (HBeAg), Hepatitis B virus e antibody (HBeAb) Tip: If the examiner wants to check both hepatitis B and liver function (hepatitis B ultrasound), it must be fasted. Normal value Hepatitis B two-and-a-half tests are divided into qualitative examination and quantitative examination. In qualitative examination and quantitative examination, the two pairs of normal values ​​of hepatitis B are different. In the two-and-a-half qualitative examination of hepatitis B, the results of the examination are usually indicated by the "+" or "-" sign, the "+" sign indicates positive, and the "-" sign indicates negative. The normal value of two pairs of hepatitis B is "-" negative, indicating that the hepatitis B virus marker is not detected in the serum. In the two-to-half quantitative examination of hepatitis B, the normal value of two pairs of hepatitis B is 1HBsAg: <0.5ng/ml (nng/ml) 2HBsAb: <=10MIU/ml [米尤(音)/ml]3HBeAg<=0.5PEIU /ml4HBeAb: When HBeAb quantification <= 0.2 PEIU / ml 5 HBcAb: <= 0.9 PEIU / ml. Three normal modes: (sequence: HBsAg, HBsAb, HBeAg, HBeAb, HBcAb) 1.-+--+ 2.-+--- 3.----- Clinical significance The sequence of the project is as follows: hepatitis B virus surface antigen HBsAg, hepatitis B virus surface antibody HBsAb, hepatitis B virus e antigen HBeAg, hepatitis B virus e antibody HBeAb, hepatitis B virus core antibody HBcAb, "-" means negative, "+" means positive, clinical significance is as follows One, nine common patterns 1-----I have not been infected with HBV in the past and present. 2----+(1) Previous infections failed to detect anti-HBs; (2) HBsAg had disappeared during recovery, anti-HBs had not appeared; (3) Asymptomatic HBsAg carriers. 3---++(1) Previously infected with HBV; (2) Recovery period of acute HBV infection; (3) A few specimens are still infectious. 1HBV infection has passed; 2 window period before anti-HBs appear. HBeAg appears later in the latent period of hepatitis B, slightly later than the appearance of HBsAg, and disappears earlier, closely related to HBV-DNA. Its clinical significance is (1) can be used as an auxiliary diagnosis and prognosis indicator for acute hepatitis B. The recovery period of acute hepatitis B often disappears with the disappearance of HBsAg. If 3-4 months after the onset of acute hepatitis B, HBeAg turns from yin to yin, anti-HBE appears, indicating a good prognosis. Onset of 3-6 months, still HBeAg (+), may be the earliest evidence of acute hepatitis conversion to chronic . (2) It is helpful to judge the infectiousness of hepatitis B patients or HBV carriers. HBeAg is present in the serum of HBsAg-positive people, indicating that Dane particles are present in the blood, and most of the HBV-DNA are positive, and the three are basically parallel. Therefore, HBeAg(+) is highly contagious. Anti-HBe(+) is generally less contagious. However, if serum HBV-DNA (+) may have HBV mutants, there is still some infectivity; (3) HBeAg positive indicates that HBV replicates in vivo. Anti-HBe occurs before and after the disappearance of HBeAg. This period is called the seroconversion period, that is, from the HBV replication period to the non-replication period. The presence of anti-HBe often suggests a weakened or terminated HBV proliferation. However, if the nucleotide sequence of the pre-C region of the HBV gene prevents the formation of HBeAg, HBV remains in the blood circulation, liver disease may continue to develop, and gradually evolve into cirrhosis; (4) HBeAg in the presence of primary liver cancer The detection rate decreased, while anti-HBe, a-FP increased. Therefore, in HBsAg(+) patients with cirrhosis, anti-HBe(+), a-FP increased, suggesting the possibility of early liver cancer; (5) maternal and child During transmission, HBeAg(+) may increase the transmission rate between mother and baby during pregnancy. 4-+---(1) Immunization with hepatitis B vaccine; (2) past infection; 3 false positive. 5-+-++ Rehabilitation after acute HBV sensation. 6+---+(1) acute HBV infection; (2) chronic HBsAg carriers; (3) weak contagious. 7-+--+ has been infected with hepatitis B virus, the virus has been basically cleared, and the body is recovering. However, some patients still have abnormal liver function and DNA positive. If there is any mutation in the virus, they still need to continue treatment and still have immunity. HBV infection, recovery period. 8+--++(1) Acute HBV infection tends to recover; (2) Chronic HBsAg carriers; (3) Infectious. It is commonly known as the "small three yang". 9+-+-+ acute or chronic hepatitis B infection. Prompt HBV replication, strong infection. It is commonly known as the "big three yang". Second, 16 rare patterns 10+----(1) Early HBV infection, acute HBV infection latency; (2) Chronic HBV carriers, weak contagious. 11+--+-(1) Chronic HBsAg carriers are easy to turn negative; (2) Acute HBV infection tends to recover. 12+-+--(1) In the early stage of acute HBV infection, (2) chronic carriers, highly contagious. 13+-+++(1) Acute HBV infection tends to recover; (2) Chronic carriers. 14++---(1) early stage of subclinical HBV infection; (2) secondary infection of different subtypes of HBV. 15++--+(1) early stage of subclinical HBV infection; (2) secondary infection of different subtypes of HBV. 16++-+-Subclinical or atypical infection. 17++-++ Subclinical or atypical infection. 18+++-+ early stage of subclinical or atypical infection. HBsAg immune complexes, new different subtypes of infection. 19--+--(1) Atypical acute infection; (2) In the early stage of infection before the onset of anti-HBc, HBsAg titers were low and negative, or false positive. 20--+-+ atypical acute infection. 21--+++ Mid-term acute HBV infection. 22-+-+-HBV has recovered after infection. 23-++--Atypical or subclinical HBV infection. 24-++-+ atypical or subclinical HBV infection. 25---+- Acute HBV infection tends to recover. Three, seven rare patterns 26+++++1 a subtype of HBsAg and atypical anti-HBs (common); 2 the process of sera from HBsAg to anti-HBs (rare). 27-+++- 28-++++ 29--++- 30+-++- 31+++-- 32++++- High results may be diseases: hepatitis B, neonatal hepatitis B, acute and chronic hepatitis, hepatitis B virus, pediatric hepatitis B virus-associated nephritis, hepatitis B virus arthritis, hepatitis B antigenemia, post-transfusion hepatitis , hepatitis B virus-associated nephritis, breast milk jaundice precautions Hepatitis B two-and-a-half test is a test, mainly to detect the hepatitis B virus antigen in the body, that is, the response of hepatitis B virus and the body, it is used to determine whether the human body is infected with hepatitis B virus, and a rough assessment of hepatitis B virus in the body. Level, so the two-to-half check of hepatitis B is not directly related to metabolism. Eating does not affect the indicators of HBV antigen antibodies, that is, it does not affect the accuracy of the test results. So no need for an empty stomach. Two-and-a-half-test of hepatitis B does not require an empty stomach examination, but two pairs of hepatitis B are often tested together with liver function or hepatitis B B-ultrasound to determine the condition of hepatitis B. The liver function and hepatitis B B-ultrasound examination must be fasted, and the diet should be light on the day before the examination. The first three days of the examination can not drink alcohol, in order to ensure the accuracy of the examination. Therefore, if you want to check the two-and-a-half of hepatitis B and liver function (hepatitis B ultrasound), you must have an empty stomach. Inspection process 1. Intravenous blood draw, laboratory test. 2. Serological examination of the virus. Not suitable for the crowd People with reduced hematopoietic function such as leukemia, various anemia, myelodysplastic syndrome, or people with thrombocytopenia should pay attention to blood draw, and should not take more or more blood. Adverse reactions and risks 1. After the blood is drawn, do not press the needle hole to avoid subcutaneous hematoma. If there is a small piece of bruise in the blood, it is slightly tender, please don't panic, you can do hot compress after 24 hours to promote the absorption of blood. The general small amount of congestion will gradually absorb in 3 to 5 days and the color will become lighter and return to normal. 2. After the blood draw, symptoms such as dizziness, vertigo, fatigue, etc. should be immediately supine, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved.