False positive for syphilis seroreactivity

The false positive of syphilis serum reaction is that after infection with syphilis, two kinds of antibodies are produced in the human body, one is the antibody directly against Treponema pallidum, and the other is the antibody against lipidoid. Antibodies against lipidoids are not directly targeted to Treponema pallidum, so they are non-specific. In addition to infection with syphilis, other diseases and physiological changes may occur, and low titers of anti-lipid antibodies may also be produced in vivo. When syphilis is diagnosed, the syphilis serological test is performed to detect both types of antibodies. The RPR test is an experiment for detecting lipid-like antibodies; and TPHA is an experiment for directly detecting Treponema pallidum. Because RPR is a test for detecting lipid-like antibodies, rather than directly detecting anti- Treponema pallidum antibodies, it is not specific, and any disease that causes lipoprotein-producing antibodies can make RPR positive. Basic Information Specialist classification: Infectious disease examination and classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Viral infection. Tips: Pay attention to normal eating habits and pay attention to personal hygiene. Prohibition of unclean sexual intercourse. Normal value The reaction was negative. Clinical significance Abnormal results in addition to syphilis, respiratory infections, pneumonia, active tuberculosis, rheumatic heart disease, subacute bacterial endocarditis, infectious hepatitis, cirrhosis, chronic nephritis, leptospirosis, leprosy, malaria, Rheumatoid arthritis, systemic lupus erythematosus and heroin addiction can cause RPR positive. The person in need of examination is clinically suspected to have syphilis infection in the doctor. It is a diagnosis of syphilis, an identification test, and an auxiliary examination for patients with the above diseases. Positive results may be diseases: anti-phospholipid syndrome in children, pneumonia in children, rheumatic heart disease Syphilis serology is an important basis for the diagnosis of syphilis, but it is not the only basis. In the diagnosis of syphilis, in addition to the results of the test, a more important basis is to learn more about the patient's life history and past medical history, as well as a detailed physical examination. After comprehensive analysis, careful judgment can be made to avoid misdiagnosis caused by false positive results of syphilis test results. Inappropriate crowd: No. Forbidden before examination: Pay attention to normal eating habits and pay attention to personal hygiene. Prohibition of unclean sexual intercourse. Requirements for inspection: Actively cooperate with the doctor. Inspection process There is a characteristic of RPR positivity caused by other causes other than syphilis, and the titer is generally low, less than 1:8. RPR experiments are prone to false positives, and doctors often do a more specific TPHA test to confirm the diagnosis of syphilis. It is worth mentioning that TPHA and other specific experiments directly against Treponema pallidum also have 1% false positives in the average person. In China, it has been reported that half of the TPHA-positive patients in a hospital have false positives. Diseases known to cause TPHA are: rheumatoid arthritis, lupus erythematosus, diabetes, colon cancer, lymphosarcoma, hepatitis C, cirrhosis, AIDS, leprosy, genital herpes, heroin addiction, and the like. In addition to disease, changes in certain physiological conditions, such as pregnancy, can also lead to RPR and TPHA. It is particularly worth mentioning that the false positive rate of syphilis serology in the elderly is higher than that of the average person, and it has been reported to be up to 2%. Many elderly people suffer from common medical conditions and can also lead to positive syphilis tests. Not long ago, a hospital in China reported that 5 patients aged 63-80 years old with internal medicine suffered from coronary heart disease, cerebrovascular disease, diabetes and leukemia. During hospitalization, RPR and TPHA were positive. Targeted false positives were excluded. Not suitable for the crowd There are no special taboos. Adverse reactions and risks There are no related complications and hazards.