Meningococcal Meningitis Immunology Test

Epidemic cerebrospinal meningitis (ECM) is still a common acute infectious disease that seriously threatens children's health. The article describes the recent epidemic of meningitis in Africa, Europe, Oceania, the United States and China. The distribution of meningococcal serogroups, serotypes and serum subtypes in the above-mentioned regions and countries, and the resistance of meningococcal bacteria to antibiotics. In order to effectively control the epidemic of the epidemic, it is necessary to strengthen the monitoring and prevention of the flow brain. To this end, it is proposed that in the epidemiological monitoring of epidemic cerebrospira, not only the morbidity and mortality of the cerebral ventricle are monitored, but also the age group morbidity should be monitored. It is also necessary to check the changes in the serogroup of meningococcus and the antimicrobial resistance of the bacteria, as well as the bacterial rate of the bacteria in healthy people and the antibody levels in the population. Injecting meningococcal polysaccharide vaccine into children is the main measure to prevent meningitis. In order to enhance the preventive effect of meningococcal polysaccharide vaccine on young children, some countries are using a combination vaccine of group C meningococcal polysaccharide and carrier protein. Basic Information Specialist classification: Infectious disease examination and classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: abnormal. Tips: Pay attention to personal hygiene, wash your clothes and increase outdoor activities. Normal value negative. Clinical significance Abnormal results; positive epidemic cerebrospinal meningitis (flowing brain) 1 convective immunoelectrophoresis positive rate of more than 80%. 2 The positive rate of latex agglutination test is 85% to 90%. The 3 diazo latex agglutination test was positive in patients with meningitis (potency 1:32 to 1:256). This method can be used to detect soluble antigens (or antibodies) in serum, cerebrospinal fluid and urine for early diagnosis of meningococcal meningitis. Need to check the crowd in the epidemic season, high fever, headache, vomiting, accompanied by changes in consciousness, physical examination of the skin, mucous membranes, spots, ecchymosis, meningeal irritation positive. Positive results may be diseases: West Nile fever considerations Inappropriate people: generally no special population. Contraindications before examination: Patients should be diagnosed early. Early report, early isolation treatment. Pathogens and serological surveillance should be carried out in areas where conditions permit. Promote the popular season with little or no children to go to public places, pay attention to personal hygiene, wash clothes, increase outdoor activities and so on. Requirements for inspection: Check with your doctor. Inspection process The immunological test is a rapid diagnosis method of the flow brain in recent years. The detection of antigens in cerebrospinal fluid is beneficial for early diagnosis, and its sensitivity and specificity are high. At present, commonly used antigen detection methods include convective immunoelectrophoresis, latex agglutination, reverse indirect hemagglutination test, bacterial synergistic agglutination test, radioimmunoassay, and enzyme-linked immunosorbent assay. The positive rate of convective immunoelectrophoresis was above 80%, the positive rate of latex agglutination test was 85%-93%, and the positive rate of A group and C group detected by synergistic agglutination test was also higher. The positive rate of reverse indirect hemagglutination test was 94.2% (cerebrospinal fluid) and 78.8% (blood). The sensitivity of enzyme-linked immunosorbent assay for detection of group A antigen was higher than that of reverse indirect hemagglutination test. Antibody detection can not be used as an early diagnosis method, and the sensitivity and specificity are poor, so the clinical application is decreasing. Convective immunoelectrophoresis, radioimmunoassay, and indirect hemagglutination test, if the serum titer of the recovery period is more than 4 times higher than the acute phase, it has diagnostic value. Not suitable for the crowd There are no special taboos. Adverse reactions and risks There are no related complications and hazards.