Anticoagulant activity test

Laboratory studies have shown that lymphocytes produced by sensitized lymphocytes in contact with specific antigens can stimulate macrophage production of tissue factor, stimulate exogenous coagulation, promote local cellulose deposition, and lead to increased blood coagulation activity. Group A hemolytic streptococcus specific antigen can increase the procoagulant activity (PCA) of peripheral blood and cardiomyocytes by lymphocyte action, all of which suggest the importance of cellular immune-mediated immune mechanism in the pathogenesis of ARF. Basic Information Specialist classification: cardiovascular examination classification: immune examination Applicable gender: whether men and women apply fasting: not fasting Tips: The application of steroids, estrogen contraceptives, anticoagulant drugs can increase anticoagulant activity. Normal value still uncertain. Clinical significance (1) Using group A hemolytic streptococcus membrane antigen as stimulator to induce peripheral blood lymphocyte PCA, the peripheral blood lymphocyte activity of patients with rheumatic carditis is significantly higher than that of rheumatic fever, rheumatoid arthritis and healthy people. The control group suggested that the PCA assay has a high specificity for the diagnosis of rheumatic carditis. (2) Studies have shown that peripheral blood lymphocyte PCA is more sensitive than ESR and CRP in reflecting rheumatic activity. In terms of reflecting immune status, it is more positive than humoral immune index CIC and anti-myocardial antibody (AMA), reflecting streptococcal infection. And the streptococcal immune response is superior to ASO. (3) Recent studies have shown that cardiomyocytes also have procoagulant activity, and cardiac cell procoagulant activity (HPCA) is only significantly elevated in the rheumatic carditis group, while in the stationary phase rheumatic heart disease, rheumatoid arthritis, other diseases The control group and the healthy control group did not increase, suggesting that HPCA elevation is a characteristic manifestation of rheumatic carditis, and has diagnostic value for rheumatic carditis. (4) The elevation of PCA is related to autoimmune diseases. The use of different antigens as stimulators to determine the corresponding PCA is helpful for the diagnosis and differential diagnosis of diseases. For example, elevated PCA in lung tissue is associated with idiopathic pulmonary fibrosis. And elevated PCA in synovial tissue cells is associated with rheumatoid arthritis. Precautions The use of steroids, estrogen contraceptives, and anticoagulants can increase anticoagulant activity. Inspection process Efficient and simple human low-density lipoprotein 125I labeling method. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.