anti-myosin antibody

Cardiac myosin (CM), also known as myosin, is a major component of thick muscle filaments and is the most structural protein in cardiomyocytes. CM consists of one heavy chain (MHC) and two light chain (MLC) subunits, and the light chain is divided into light chain I (MLC-I) and light chain II (MLC-II). CM is similar in function to skeletal muscle, but differs in amino acid organization and structure. Therefore, the formed antigenic determinants are also different from skeletal muscle and smooth muscle. Therefore, a myocardial-specific antigen can be provided to produce a myocardial-specific anti-mycopherin antibody (AcMA). Myosin causes an immune response in patients with viral myocarditis and dilated cardiomyopathy, producing specific antibodies. It is currently believed that there are two possible mechanisms: 1 viral infection or other causes of myocardial tissue necrosis leading to the release and exposure of myosin, triggering the individual's autoimmunity. 2 Viral molecules have similar antigenic determinants to myosin. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: There may be viral myocarditis and dilated cardiomyopathy. Tips: According to the nutritional status of the whole body, milk, eggs, fruits, soy milk, etc. are given in the meal. Normal value negative. Clinical significance Anti-myosin antibodies are specific antibodies to viral myocarditis and dilated cardiomyopathy. 42% of patients with viral myocarditis had anti-myosin antibodies, which was significantly higher than other heart disease groups and healthy controls. Similarly, 46% of patients with dilated cardiomyopathy have anti-myosin antibody positive, suggesting that myosin is also the main antigen of dilated cardiomyopathy. Detection of anti-myosin antibody can be used as adjunctive diagnosis of viral myocarditis and dilated cardiomyopathy. index. When the myocardial cell membrane ruptures, AcMA specifically binds to CM, indicating the presence of active myocardial damage. Precautions The more severe the myocardial cell damage, the higher the serum CMLC level. Because of its strong immunological specificity, CMLC is a biochemical indicator for the diagnosis of AMI and the study of myocardial injury and protection. Inspection process The same as Western-blot method, ELISA method, indirect immunofluorescence method. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.