anti-RNP antibody

The nuclear RNP antigen antibody system is the second antigen-antibody system characterized by systemic autoimmune diseases. This system is nuclear RNP because it is located in the nucleus and the antigenicity of this system can be destroyed by nucleases and proteolytic enzymes. Recent molecular studies have shown that nuclear RNP belongs to a large family of snRNPs, and autoantibodies with this specificity can react with U1RNP particle components, one of the subfamilies of snRNPs. U1RNP particles contain A, C and 70 kD proteins, and autoantibodies react with antigenic determinants on A, C and 70 kD proteins. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Tips: Try to eat less and eat as much as possible, and arrange your diet reasonably. Normal value negative. Clinical significance Antinuclear RNP antibodies are found in nearly 32% of SLE patients, and this autoantibody is found in almost all MCTD patients. In SLE, the anti-nuclear RNP autoantibody is only a large antigen and one antibody in the antibody profile, while in the MCTD, the nuclear RNP (U1RNP) antigen antibody system is predominant. Precautions High titers and anti-U1RNP (especially high titer anti-70 kD) antibodies are considered diagnostic markers for MCTD. Inspection process Immunoblotting (WB) and indirect immunofluorescence (IIF). Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.