Anti-Jo-1 antibody

The target antigen against Jo-1 is a histidyl-tRNA synthetase. In an in vitro experiment, anti-Jo-1 can inhibit enzyme activity, and the antigen is a dimer having a subunit molecular weight of 50×103. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Prompt for polymyositis and tenosynovitis. Tips: Try to eat less and eat as much as possible, and arrange your diet reasonably. Normal value Normal person is negative. Clinical significance The positive rate of anti-Jo-1 in polymyositis and dermatomyositis is 20% to 40%. The triad of anti-Jo-1 positive patients is listed below. Polymyositis. Polyarticular synovitis, joint pain, non-invasive degenerative arthritis, tenosynovitis. Alveolar fibrosis or pulmonary fibrosis. Symptoms associated with scleroderma are occasionally associated with it. This group of syndromes was named Jo-1 syndrome or anti-synthetase syndrome; the latter was derived from other antibodies against aminoacyl-tRNA synthetase. Anti-Jo-1 positivity has a predictive value of more than 95% for these or at least one of these syndromes; usually, as a single or missing symptom occurs, in general, antibodies are produced earlier than symptoms. Anti-Jo-1 is rarely detected in children, and more than 90% of anti-Jo-1 positive Caucasian patients have HLA-DR3. Precautions The Hep-2 nucleus is negative in IFT because its antigenic group aminoacyl-tRNA synthetase is located in the cytoplasm. The vast majority are cytoplasmic. Inspection process Precipitation methods, such as immunodiffusion or reverse phase immunoelectrophoresis, such as thymus extract as an antigen. The immunoblot was established by culturing the cell extract and purifying the recombinant antigen, and the molecular weight of the positive band was about 50×103. The ELISA method is established by recombinant or purified antigen. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.