Sarcoidosis antigen (Kveim) test

A 1:10 physiological saline suspension liquid was prepared as an antigen in lymph nodes or spleen tissues of patients with acute nodules. 0.1-0.2 ml of the suspension was taken for intradermal injection, and 10 days later, skin changes at the injection site were observed. Because of the lack of standard antigens, the application of this inspection is limited and has been gradually eliminated in recent years. The sarcoidosis antigen (Kveim) test uses the lymph node or spleen tissue of patients with sarcoidosis to perform antigen detection experiments. Sarcoidosis is a multi-system, multi-organ granulomatous disease. Often invaded the lungs, bilateral hilar lymph nodes, more than 90% of the clinical changes in the lungs, followed by skin and eye lesions, superficial lymph nodes, liver, spleen, kidney, bone marrow, nervous system, heart, etc. Can be affected. The disease is a self-limiting disease, most of which have a good prognosis and a trend of natural remission. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Prompt for acute sarcoidosis. Tips: Pay attention to maintaining a good diet. Normal value negative. Clinical significance After 10 days, purple-red papules appeared at the injection site, and after 4-6 weeks, they spread to 3-8 mm, forming a granuloma, which was a positive reaction. The skin with positive reaction was removed for tissue diagnosis, and the positive rate was about 75%-85%. There is a 2%-5% false positive reaction. This test can be turned negative as the disease is relieved. Precautions Before testing: Pay attention to maintaining a good diet. During the examination: relax the body and follow the doctor's instructions to do the relevant tests. Inspection process A 1:10 physiological saline suspension liquid was prepared as an antigen in lymph nodes or spleen tissues of patients with acute nodules. 0.1-0.2 ml of the suspension was taken for intradermal injection, and 10 days later, skin changes at the injection site were observed. Because of the lack of standard antigens, the application of this inspection is limited and has been gradually eliminated in recent years. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.