Keratin 19 Fragment (CYFRA21-1)

Cytokeratin 19 fragment (CYFRA211) CYFRA211, also known as cytokeratin, is a new tumor marker developed in recent years [. It is a fragment of cytokeratin 19 (CK19) produced during the differentiation of cancer cells. CK19 is a characteristic protein component of epithelial cell intermediate filaments and is present in a variety of normal epithelial tissues. When the epithelial cells are transformed into tumors, the keratin structure is unchanged but the content is increased. Due to the necrosis and dissolution of the tumor cells, the soluble fragment of CK19, CYFRA211, can be released into the blood. CYFRA211 is present in the cytoplasm of tumor cells of epithelial origin such as lung cancer and esophageal cancer. Basic Information Specialist classification: Oncology examination classification: other examinations Applicable gender: whether men and women apply fasting: not fasting Tips: Observing the dynamic monitoring of clinical lung cancer surgery and the efficacy of radiotherapy before and after chemotherapy is an important auxiliary indicator. Normal value <3.3 ng/ml. Clinical significance The positive rate of CYFRA21-1 was found in lung cancer patients with a positive rate of 64.5%, of which squamous cell carcinoma was about 80.0%, adenocarcinoma was about 63.6%, and small cell lung cancer was about 41%. The detection of serum CYFRA21-1 has certain reference value for the clinical stage of lung cancer patients. And as the clinical stage progresses, the measured value is getting higher and higher. The level of CYFRA21-1 is related to the degree of differentiation of clinical lung cancer patients, and the lower the degree of differentiation, the higher the content. Precautions Observing the dynamic monitoring of clinical lung cancer surgery and the efficacy of radiotherapy before and after chemotherapy is an important auxiliary index. Inspection process The free part of the small molecule is adsorbed by the surface activity of the activated carbon. For example, a layer of dextran is coated on the surface of the activated carbon to make a mesh having a certain pore diameter on the surface, thereby allowing small molecules of free antigen or hapten to escape and being adsorbed, while the macromolecular complex is excluded. After the antigen and the antibody are reacted, the dextran-activated carbon is added and allowed to stand for 5 to 10 minutes, so that the free antigen is adsorbed on the activated carbon particles, and the particles are precipitated by centrifugation, and the supernatant contains the labeled antigen. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.