133Xe Cerebral Blood Flow Measurement and Imaging

133Xe cerebral blood flow measurement and imaging 133Xenon (133Xe, 氙-133) is a fat-soluble inert gas. After entering the blood circulation, it can pass freely through the normal blood-brain barrier, is taken up by brain cells by diffusion, and then quickly cleared from brain tissue. The clearance rate of brain tissue is positively correlated with rCBF. The clearance rate of 133Xe in brain tissue of each region is determined, and rCBF and CBF can be calculated. Basic Information Specialist classification: growth and development check classification: CT Applicable gender: whether men and women apply fasting: not fasting Tips: Check before taboo: Stop taking sedatives 24 hours before the test. Normal value The CBF reference value measured by 99Tcm-HMPAO was 44.2±4.5ml/100g/min, and the CBF reference value measured by 133Xe was 67.83±8.95ml/100g/min, and the left and right brain rCBF were similar. Clinical significance Abnormal results According to the calculated rCBF and CBF, the diagnosis of cerebral ischemia, cerebral infarction and the diagnosis and differential diagnosis of Alzheimer's disease, the location diagnosis of epileptic foci. The people who need to be examined have cerebral ischemic diseases, cerebral infarction, Alzheimer's disease, and epilepsy. Precautions Pre-examination contraindications: Stop taking sedatives, stimulants and other drugs that act on the nervous system 24 hours before the test to avoid the formation of illusions during the examination and affect the judgment of the test results. Oral potassium chlorate 400mg was taken 30 minutes before the examination to close the choroid plexus; 10 minutes before the injection of the imaging agent, black eye mask and earplugs should be worn until 10 minutes after injection to remove, and the eyes were closed and quietly rested before imaging. Requirements for inspection: The examination must be carried out within 3 hours after the meal. If you cannot eat before the examination, you should follow the doctor's instructions, orally take 50 grams of powdered sugar or 40 ml of 50% glucose intravenously to prevent hypoglycemia. The result of the inspection. Inspection process The subject was placed on his back, and the head was placed in a helmet of a multi-probe detecting device, and a 133Xe 133Xe-O2 mixed gas of 185 MBe/L was inhaled for 1 min, followed by inhalation of air for 15 min. The multi-probe system was started to record for 10~15min, and the rCBF and the gray matter flow distribution map of the corresponding parts of each probe were obtained by computer processing. If tomographic imaging must be completed in a short time using a high-speed rotation and high-sensitivity SPECT system. Not suitable for the crowd Inappropriate people: not yet known.