genetic screening

Genetic screening refers to the detection of individuals or couples whose offspring have an increased risk of hereditary diseases, or the use of simple, feasible, noninvasive methods for prenatal screening for high incidence, hereditary diseases, and congenital malformations. The venous blood of pregnant women was taken, and the concentrations of serum villous gland hormone, estriol, fetal alpha-protein, and statin were measured. Combined with the age, weight, and number of weeks of pregnancy, the risk of Down's syndrome in the fetus was calculated by the computer. Basic Information Specialist classification: eugenics and superiority examination classification: biochemical examination Applicable gender: whether men and women apply fasting: not fasting Tips: Before the inspection: pay attention to rest, do not eat and drink. Normal value Down's syndrome blood test score is less than 1/700 (low risk). Sugar sieve blood glucose value <7.8mmol. Fetal malformation, villus biopsy normal growth of the fetus. Detachment complete cytomegalovirus IgG critical 25~40; cytomegalovirus IgM critical 10~15; Toxoplasma IgG critical 10~20; Toxoplasma IgM critical 450~540; Rubella; Virus IgG critical 10~20; Rubella virus IgM critical 2.5~3.5. Clinical significance Abnormal result The blood test for Down's syndrome is greater than 1/270 (high risk population); Sugar sieve blood glucose value ≥ 7.8mmol; Fetal malformation without brain, open spina bifida, severe cardiac structural malformation, upper and lower limb loss, kidney deficiency (no kidney), hydrocephalus, pulmonary cysts, etc.; Fetal abnormalities caused by chromosomal abnormalities, genetic abnormalities, structural abnormalities and other external factors in the villus biopsy; Defibrillation complete cytomegalovirus IgG greater than 40 (positive); cytomegalovirus IgM greater than 15 (positive); Toxoplasma IgG greater than 20 (positive); Toxoplasma IgM greater than 540 (positive); rubella virus IgG greater than 20 (positive); Rubella virus IgM is greater than 3.5 (positive). The group of pregnant women who need to be examined. Precautions Down syndrome, a full set of depolarization: Inappropriate crowd: no. Before the inspection: pay attention to rest, do not eat and drink. When checking: Relax your body and actively cooperate with your doctor. Sugar sieve: Inappropriate crowd: pregnant women in early or late pregnancy Before the test: pay attention to rest, light diet, fasting. When checking: Relax your body and actively cooperate with your doctor. infant deformity: Inappropriate crowd: early and late pregnancy Before the inspection: pay attention to rest and remove the metal ornaments. When checking: Relax your body and actively cooperate with your doctor. Villus biopsy: Inappropriate crowd: Any maternal from the last menstrual period, more than 12 weeks of gestational weeks; maternal vaginal infection; uterine shape of the same maternal, such as uterine fibroids or double-horned uterus; severe vaginal bleeding. Before the inspection: pay attention to rest. When checking: Relax your body and actively cooperate with your doctor. Inspection process Down's syndrome: The venous blood of pregnant women was taken, and the concentrations of serum villous gland hormone, estriol, fetal alpha-protein, and statin were measured. Combined with the age, weight, and number of weeks of pregnancy, the risk of Down's syndrome in the fetus was calculated by the computer. Sugar sieve: Before the screening for fasting for 12 hours, dissolve 50 grams of glucose powder in 200ml of water, drink it in 5 minutes, start the first time with the first mouth, and check the blood sugar after 1 hour. infant deformity: The subject took the supine position and was examined by the pregnant woman's abdomen. First, the fetal growth and development were comprehensively observed. The fetal head double top diameter, femur length, amniotic fluid index, placental orientation, thickness, grade, and repeated suspected abnormal parts were carefully scanned. Check, focus on the organs and systems of abnormal fetal development, whether there is fetal complex malformation. Villus biopsy: The subject was supine, knee flexed, supported by ankle or knee; the doctor under the guidance of ultrasound scanning, the catheter was delivered to the placental villus via the vagina and cervix, and a small amount of fluff was taken with an empty needle for examination. Complete set of depolarization: The venous blood of pregnant women was taken and the concentration of rubella, toxoplasma, cytomegalovirus antibody IgG and IgM in the blood was examined. Not suitable for the crowd Inappropriate crowd: No.