TSH receptor antibodies

Thyroid stimulating hormone receptor antibody (TRAb), also known as membrane receptor antibody, is an antibody that directly acts on the TSH receptor on the thyroid cell membrane, and belongs to the immunoglobulin IgG. According to its action, it can be divided into the following three types of thyroid stimulating antibodies. (TSAb), also known as thyroid-stimulated immunoglobulin (TSI), binds to the TSH receptor on the thyroid follicular membrane, stimulates goiter and enhances its functional activity, which is the main cause of Graves' disease. 2 thyroid function inhibitory antibody (TFIAb), also known as thyroid function inhibitory immunoglobulin (TFII), combined with TSH receptor, can inhibit thyroid function, causing hypothyroidism. 3 Thyroid growth-stimulated immunoglobulin (TGI) can stimulate goiter, but does not affect its function. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Tips for possible thyroiditis. Reminder: Each laboratory needs to establish a corresponding normal reference range according to its experimental conditions and methods. Normal value <15U/L. Clinical significance (1) TRAb is of great significance for the diagnosis, treatment and prognosis of Graves' disease. The positive rate of TRAb in patients with Graves disease can reach more than 95%, so it can be used as the basis for diagnosis of Graves disease. When anti-thyroid drugs are used, the activity of TRAb can be significantly decreased with the relief of the disease. When the thyroid hormone level in the blood is normal, if the TRAb gradually decreases, and then turns negative, the possibility of recurrence after stopping the drug is small; After the TRAb continues to be positive, the treatment effect is not good, and the possibility of recurrence after stopping the drug is high. (2) TRAb may also be positive in patients with hypothyroidism and autoimmune thyroiditis, contributing to the etiology of the above diseases. Precautions Each laboratory needs to establish a corresponding normal reference range according to its experimental conditions and methods. Inspection process Radioreceptor Analysis (RRA). Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.