Hyaluronidase

Hyaluronidase is mainly taken up by liver endothelial cells, which can correctly respond to the amount of liver fibrosis and reflect the damage of liver cells. Therefore, it is a hard indicator for judging liver fibrosis and cirrhosis. It is an enzyme capable of hydrolyzing hyaluronic acid (hyaluronic acid is a component of the tissue matrix which has the function of restricting the diffusion of water and other extracellular substances), and can be used for temporarily reducing the viscosity of the intercellular substance in the human body, and can promote subcutaneous infusion and localization. Accumulated exudates or blood accelerate the diffusion and facilitate absorption, which is an important drug diffusion agent. It is used as a drug penetrant in clinical practice to promote the absorption of drugs and promote local edema or hematoma dissipation after surgery and trauma. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: not fasting Tips: Taboos during check-up: Can not eat before the test, blood test requires fasting, fasting time is generally 8 to 12 hours. Normal value The normal value is 50-180 ng/mL. Clinical significance Abnormal results: blood HA was higher than 100 μg / L, indicating the presence of cirrhosis and liver fibrosis. Need to check the crowd: liver cirrhosis, liver fibrosis patients. Precautions Taboo before inspection: 1. Be careful not to take the drug before the test, because some drugs will increase the burden on the liver, causing temporary damage to the liver function, which will lead to the accuracy of the liver function test results. 2. Pay attention to ensure adequate sleep before exercise, do not exercise vigorously, which may cause elevated transaminase, thus affecting the test results. 3. You must not drink alcohol the day before. Drinking alcohol will cause an increase in transaminase and affect the test results. 4. Accept the patient's consent when undergoing a liver biopsy. Taboo when checking: 1. Can not eat before the examination, blood test requires fasting, fasting time is generally 8 to 12 hours. 2 Take care when performing a liver biopsy, do not hurt the patient. Inspection process Under local anesthesia, a small amount of live liver tissue was taken through a body surface puncture and subjected to pathological examination under a microscope. Not suitable for the crowd Not suitable for the crowd: no. Adverse reactions and risks No related complications and hazards have been found.