Saline infusion test

The saline infusion test is carried out by the following principle. Under normal circumstances, after the saline infusion, the blood sodium and blood volume increase, and a large amount of sodium salt enters the nephron distal convoluted tubule, which can inhibit the secretion of renin in the renal glomerulus. Thereby inhibiting the secretion of angiotensin-aldosterone and reducing the levels of renin, angiotensin and aldosterone in the blood. Basic Information Specialist classification: growth and development check classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Reminder: Requirements for inspection: Actively cooperate with the doctor's request. Normal value In this test, the levels of renin, angiotensin and aldosterone in normal human blood were decreased. Clinical significance Abnormal results: 1. Patients with primary aldosteronism, especially in patients with adrenal cortical aldosterone secretory tumors, high sodium has no inhibitory effect on aldosterone secretion, and plasma aldosterone levels are not inhibited. 2, patients with idiopathic aldosteronism, can have a false negative reaction, that is, aldosterone secretion is inhibited. People who need to be examined: those with suspected symptoms of primary aldosteronism and idiopathic aldosteronism. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process [method] 1. The subject ingested a 120 mEq sodium diet for at least 3 days. 2, stay in bed overnight. 3. At 8 o'clock in the morning, blood samples were taken for PRA, Aldo and cortisol as controls. 4. Drip 1250 ml of physiological saline from 8AM to 12AM. 5. At the end of the infusion, blood was again taken for PRA, Aldo, and Cortisol. [Result analysis] If the patient's basic aldosterone levels are higher than normal, renin and angiotensin are inhibited, and the level of aldosterone is still high after saline infusion, which is not inhibited, thus supporting the diagnosis of primary aldosteronism. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks No related complications or hazards.