selective proteinuria index

The Selective Proteinuria Index is an auxiliary test used to check whether kidney function is normal. The renal clearance rate of plasma proteins with large differences in molecular weight is often determined clinically, and the ratio is calculated as the selectivity index (SPI). The blood and urine concentrations are usually determined by immunoturbidimetric assay or one-way immunodiffusion method using transferrin (molecular weight 79,000) and IgG (molecular weight 170,000), respectively. This test can objectively reflect the severity of glomerular lesions, and can be used as a predictor of the therapeutic effect of immunosuppressive agents such as hormones in nephrotic syndrome. It is worth mentioning that nephrotic syndrome caused by renal vein embolism, proteinuria in patients with renal amyloidosis and hereditary nephropathy is also highly selective, but not effective against hormones and immunosuppressive agents. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Tips: Maintain a normal diet and sleep. Normal value The SPI boundary is moderately selective between 0.1 and 0.2, which is a normal clinical manifestation. Clinical significance Abnormal results: high selectivity is seen in minimally pathological nephropathy, sensitive to hormones, and good prognosis. Membranous or membrane proliferative nephritis often exhibits low selectivity or is called non-selective, indicating that macromolecular proteins have passed through the glomerular filter in a large amount, have poor response to hormones, and have a poor prognosis. This test can objectively reflect the severity of glomerular lesions, and can be used as a predictor of the therapeutic effect of immunosuppressive agents such as hormones in nephrotic syndrome. It is worth mentioning that nephrotic syndrome caused by renal vein embolism, proteinuria in patients with renal amyloidosis and hereditary nephropathy is also highly selective, but not effective against hormones and immunosuppressive agents. People who need to be examined: suspected to be a kidney disease patient. Precautions Taboo before check: Maintain normal diet and sleep. Requirements for examination: The patient actively cooperates with the doctor and the doctor carefully operates to avoid the result. Inspection process Renal function test. Not suitable for the crowd Inappropriate people: Generally, there is no suitable for the crowd. Adverse reactions and risks No related complications or hazards.