glomerular function test

The glomerular function test is an auxiliary test to check whether glomerular function is normal. The basic function of the kidney is to excrete metabolic waste, regulate and maintain water, electrolytes, acid-base and osmotic pressure balance and secrete endocrine hormones. Excretion of urine is one of the main physiological functions of the kidney, and the daily urine formed by glomerular filtration is up to 180 liters. Among them, the test items were serum urea nitrogen (BUN), serum creatinine (Cr), and endogenous creatinine clearance (Ccr). Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Tips: It is best not to have breakfast, and at least three days before the test should be light diet, do not drink alcohol, overeating or excessive fatigue, so as not to affect the test results. Normal value (1) Determination of serum urea nitrogen (BUN), reference value of adult 3.2 ~ 7.1mmol / L; children l. 8 ~ 6.5mmol / L. (B) blood creatinine (Cr) determination reference value of whole blood creatinine 88 ~ 177μmol / L. (3) Determination of endogenous creatinine clearance (Ccr) The reference value is 80 to 120 ml/min for adults (body surface area is 1.73 m2). Clinical significance Abnormal results: (1) Determination of serum urea nitrogen (BUN), clinical significance serum urea nitrogen can reflect glomerular filtration function, various kidney diseases can increase BUN, and often affected by extra-renal factors, so BUN determination is not sensitive It is also not a specific indicator of renal dysfunction. (B) determination of serum creatinine (Cr), clinical significance in the control of exogenous creatinine intake, the concentration of Cr in the blood depends on the glomerular filtration capacity, so the determination of blood Cr concentration can reflect the glomerulus Filter function. (3) Determination of endogenous creatinine clearance rate (Ccr), clinical significance Ccr is a sensitive indicator for judging glomerular damage, which can reflect glomerular filtration function earlier, when Ccr is reduced to below normal value of 80%, large Some patients are still in the normal range of BUN and Cr. People who need to be examined: suspected to be dysfunctional glomeruli. Precautions Taboo before the test: It is best not to eat breakfast, and at least three days before the test should be light diet, do not drink alcohol, overeating or excessive fatigue, so as not to affect the test results. Requirements for examination: The patient takes the urine according to the doctor's examination, the doctor carefully checks and carefully observes the result. Inspection process First, serum creatinine (Scr) Under normal circumstances, the rate of creatinine production in the body is about 1mg / min, when the glomerular filtration function is more than 1/2, Scr gradually rises, and the creatinine value measured by fasting blood is not affected by exogenous creatinine. The normal value of serum creatinine was <132.6 μmol/L (1.5 mg/dl). When the glomerular filtration function is significantly impaired, the Scr is increased and the reduction is not clinically significant. Second, creatinine clearance rate (Ccr) Creatinine is a metabolite of creatine in the human body. The excretion of creatinine in normal people is mainly through the filtration of glomeruli, and the creatinine in the original urine is not reabsorbed by the renal tubules. The production of creatinine in human plasma can be both internal and exogenous, while exogenous creatinine does not affect the determination of serum creatinine in the morning fasting or breakfast, and endogenous creatinine can be used as an indicator substance for the determination of GFR. Third, blood urea nitrogen (BUN) The blood urea nitrogen is the end product of human protein metabolism. The amount of urea produced depends on the protein intake in the diet, the rate of tissue protein decomposition and the state of liver function. The urea is mainly excreted by the kidney, and the urea excreted by the kidney every day is about 10~. 30g, blood urea nitrogen will only rise when GFR drops to 1/2 or more. Not suitable for the crowd Inappropriate people: Generally, there is no suitable for the crowd. Adverse reactions and risks No related complications or hazards.