Myosin test

The myosin test is a test for determining whether or not a patient with high blood pressure is high in renin-type hypertension. In this test, the aspartic acid at the 1 position of angiotensin II and the phenylalanine at the 8 position are replaced by muscle amino acids and alanine, respectively, which have the effect of competing with angiotensin II for receptors, so that blood pressure The decrease in angiotensin I in the body does not decrease. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Tips: Pay attention to the normal diet before the examination, pay attention to normal work and rest, and prevent endocrine disorders. Normal value The blood pressure of this test did not increase significantly with the increase of angiotensin. Clinical significance Positive indicator: 1 in 10 minutes, blood pressure decreased 4.0/2.6kPa (30/20mmHg); 2 diastolic blood pressure decreased ≥9.3%; 3 plasma renin activity ≥14ngAI/ml?hr); 4 renin activity response value / control value ≥2.2 , indicating that the patient belongs to high renin type hypertension. Hyperrenin-type hypertension is vasoconstrictive hypertension. 90 to 95% of patients with renal vascular hypertension showed positive results, and the surgical results were good. However, a small number of patients with high renin-type essential hypertension also have antihypertensive reaction after injection of propofol anti-pressin, which should be noted. Abnormal results: reduced renal blood supply and decreased intrarenal pressure after renal artery stenosis promote increased secretion of renin, leading to an increase in angiotensin and high blood pressure. People who need to be examined: hypertension caused by vasoconstrictive diseases such as high renin-type hypertension. Precautions Inappropriate crowd: temporarily unknown Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process The aspartic acid at the 1 position of angiotensin II and the phenylalanine at the 8 position are replaced by muscle amino acids and alanine, respectively, and compete with angiotensin II for receptor action, which lowers blood pressure in vivo. Angiotensin I does not decrease. According to the results, it is judged whether hypertensive patients are hyperrenal hypertension Not suitable for the crowd There are no special taboos. Adverse reactions and risks No related complications or hazards.