β2-microglobulin clearance assay

The β2-microglobulin clearance test is an auxiliary examination method for checking whether the urination function is normal. 22-microglobulin is a small molecular protein with a molecular weight of 11800. β2-microglobulin (β2-MG) is produced by lymphocytes, platelets, and polymorphonuclear leukocytes. The ability of tumor cells to synthesize β2-microglobulin is also strong. . The β2-microglobulin entering the blood circulation can be freely filtered from the glomerulus, about 99.9% is reabsorbed by the proximal convoluted tubule, and only 0.1% is excreted from the terminal urine. When the β2-microglobulin synthesis increases or the renal excretion decreases in the body. It can cause an increase in blood β2-microglobulin, so β2-microglobulin is a sensitive indicator for evaluating renal function, and is also an important indicator in tumor diagnosis and differential diagnosis. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Tips: It is best not to have breakfast before the examination, and the diet should be light at least three days before the examination. Normal value 23 to 62 μl/min. The synthesis rate of β2-microglobulin in normal humans and the release from the cell membrane are quite constant. β2-microglobulin can be freely filtered from the glomerulus, 99.9% is absorbed in the proximal tubule, and no longer flows back into the blood. Under normal circumstances, the amount of β2-microglobulin discharged remained at a stable level. Clinical significance Abnormal results: increased renal tubular damage. This test is a reliable indicator of the extent of tubular damage and is particularly helpful in the detection of light patients. People who need to be examined: patients with kidney disease. Precautions Taboo before the test: It is best not to have breakfast before the test, and the diet should be light at least three days before the test, do not drink alcohol, overeating or excessive fatigue, so as not to affect the test results. Requirements for examination: The patient should actively cooperate with the doctor and the doctor should check it carefully to avoid the result. Inspection process On the experimental day, the patient took a normal diet. Urinary every three hours within 24 hours of the day and night, collected in the clean sample bottle. The ratio of normal daytime urine volume to nocturnal urine volume is 3~4:1; the 12-hour nighttime urine volume does not exceed 750 ml; the highest proportion of urine is above 1.020. The difference in the highest proportion is not less than 0.009. At night, the urine volume exceeds 750 ml. This phenomenon is often an early manifestation of renal insufficiency; the highest specific gravity of less than 1.08 indicates that the renal dysfunction is incomplete; the specific gravity of each specimen is very small, and the urine specific gravity is mostly fixed at about 1.010, indicating that the kidney is concentrated. Severe obstacles; daytime urine is fixed at 1.018 or higher, mostly dehydrated patients. Not suitable for the crowd Inappropriate people: Generally, there is no suitable for the crowd. Adverse reactions and risks No related complications or hazards.