Urinary phenol red excretion test (PSP)

The urinary phenol red excretion test (PSP) is an auxiliary test method for checking the urine for normality. Phenol red (PSP) is a harmless dye to the human body. After injection into the human body, most (94%) are actively excreted by the proximal tubular epithelial cells and discharged from the urine. Therefore, the determination of phenol red in the urine The discharge amount (phenol red excretion rate) can be used as a rough indicator for judging the function of proximal tubule excretion. Through this examination, the corresponding symptoms can be judged. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Tips: Do not eat after 9:00 pm the day before the test. Drink water. Check that you can't eat or drink on the day. Do not drink diuretic beverages such as tea or coffee before and during the test. Can not take laxatives such as phenolphthalein, mountain road, rhubarb, etc., and can not use aspirin, phenylbutazone, penicillin and other drugs. Normal value 15min 0.25 ~ 0.51 (0.53); 30min0.13~0.24 (0.17); 60min0.09~0.17(0.12); 120min0.03~0.10(0.06); The total amount of 120 min is 0.63 to 0.84 (0.70). Clinical significance Abnormal result 1. (1) Chronic nephritis, chronic pyelonephritis, renal arteriosclerosis and other significant tubular damage, the amount of excretion is significantly reduced, and the degree of disease is roughly consistent. (2) In acute nephritis, since the main lesion is in the glomerulus, the excretion amount can be roughly normal. 2. The phenol red excretion test can also be used to reflect the degree of renal damage, such as 15 minutes of excretion less than 12%, 2 hours of total discharge less than 55%, and no extrarenal factors, it indicates renal insufficiency. For example, if the total amount discharged in 2 hours is only 40% to 55%, it is mild renal damage; 25% to 39% of moderate damage; 11% to 24% is severe damage; 0% to 10% is extremely serious damage. . People who need to be examined: those with abnormal urine. Precautions Taboo before the test: Do not eat after 9:00 pm the day before the test. Drink water. Check the morning after getting up and do not eat or drink water, which is convenient for inspection. Requirements for inspection: (1) When injecting phenol red, use a tuberculin syringe to absorb 1 ml very accurately, completely inject it into the vein, and do not leak it; (2) Do not drink diuretic beverages such as tea or coffee before and during the test. Can not take phenolphthalein, mountain road, rhubarb and other laxatives, because it can change color with alkali, can not use aspirin, phenylbutazone, penicillin and other drugs, because the drug is competitive with phenol red, can block phenol red from the kidney The small tube is discharged, resulting in a decrease in phenol red excretion; (3) urine must be on time, urine must be exhausted, the amount of urine should not be less than 30ml in 15 minutes, otherwise the results will be low; colorimetry should be carried out as soon as possible after urine retention, especially aldehyde urine, should be immediately colorimetric In case of fading. Sodium hydroxide should not be too much, otherwise the result will be inaccurate; (4) The urinary tract must be unobstructed, and there must be no obstruction or bladder retention. Inspection process The doctor collects the patient's urine, passes the separation test of the urine by the laboratory, and measures the urine output of phenol red in the urine (phenol red excretion rate), which can be used as a rough indicator to judge the function of proximal tubule excretion. The doctor should be careful when checking to avoid errors. Not suitable for the crowd Inappropriate people: Generally, there is no suitable for the crowd. Adverse reactions and risks No obvious complications and harms.