Water Loading ADH Inhibition Test

The water load ADH inhibition test is to check for the presence of vasopressin secretion (SLADH). SLADH refers to an abnormal increase in the secretion of anti-diuretic hormone (ADH) in the body or its activity is abnormal, resulting in syndromes such as water retention, increased urinary sodium excretion, and dilute hyponatremia. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: Water load ADH inhibition test positive urine osmotic pressure Positive: Water load ADH inhibition test positive urine osmotic pressure> blood osmotic pressure. Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Normal value Water load ADH inhibition test positive urine osmotic pressure> blood osmotic pressure. Water load ADH inhibition test negative urine osmotic pressure < blood osmotic pressure. Clinical significance Abnormal results: clinical manifestations of inappropriate secretion of antidiuretic hormone. The severity of clinical symptoms is related to the secretion of ADH, but it also depends on the degree of water load. Most patients do not exhibit typical symptoms when limiting water. However, if water load is applied, water retention and hyponatremia may occur, and there may be progressive weakness, fatigue, and blood sulphate <125mmol/L may cause confusion, when blood sodium falls below 110mmol/L. May have medullary paralysis, a stupor state, positive pyramidal tract sign, and even coma, convulsions, severe cases can be fatal. Although the water in the patient is retained in the cells, it generally does not exceed 3 to 4 L, so there is no swelling due to weight gain. The people who need to be examined are: water retention and hyponatremia, medullary paralysis, stupor state, positive pyramidal tract sign and other suspected cases of inappropriate secretion of antidiuretic hormone. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. This test has certain risks and should be selectively performed (blood sodium > 125mmol / L, without obvious symptoms). Inspection process Method: Drink plenty of water in a short time (20ml/kg body weight, drink in half an hour). Normal people can discharge 80% within 5 hours, urine osmotic blood osmotic pressure; antidiuretic hormone secretion patients with 40% of urine output, urine osmotic pressure> blood osmotic pressure. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks No obvious complications and harms.