Glucose-suppressed growth hormone test

Glucose-inhibiting growth hormone test is carried out by the following principle. Hypothalamic GH neurons have a sugar receptor that regulates GH secretion. After glucose load, GHRH secretion or excitatory somatostatin (SS) is inhibited by hypothalamic glycoside receptors. Secretion reduces the secretion of pituitary GH. Basic Information Specialist classification: Digestive examination classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Normal value [Normal value] GH < 3 ug / L after 100 g of glucose load. Clinical significance Acromegaly: usually due to GH secretory pituitary adenoma. Abnormal results: About 1/3 GH level was partially inhibited in patients with acromegaly (GH value inhibition >50%, but still >3ug/L); about 1/2 of patients GH fluctuated within 50% of the control value, not affected Inhibition; about 20% of patients showed an abnormal reaction, and GH increased instead of more than 50% of the control value. The people who need to be examined are: progressive bone growth, increased hand and foot, thickened skin, rough face and other main symptoms of acromegaly. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process [method] 1, oral glucose 100 grams (patients with diabetes can be replaced with 125 grams of rice porridge). 2. Blood glucose and GH were measured at 0, 30, 60, 120, and 180 minutes, respectively. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks No obvious complications and harms.