Glucose insulin release test

The glucose insulin release test was carried out by the following principle. The use of oral glucose can stimulate the islet β cells to cause an increase in insulin release, which can reflect the functional status of β cells, and thus has certain value for the diagnosis, classification and guiding treatment of diabetes. Basic Information Specialist classification: Digestive examination classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Normal value The fasting plasma insulin concentration of normal people is 5-20mU/L, and reaches the highest peak 30-60 minutes after oral administration of 100g glucose, about 8-10 times the basic value, and returns to the original level after 3 hours. Clinical significance The patient had fasting and 2 hours of normal blood glucose, normal fasting insulin concentration, 12-hour fasting insulin concentration, and normal insulin release after glucose stimulation. Can exclude diseases such as diabetes and insulinoma. Abnormal result 1. Diabetes-related abnormal symptoms: (1) dry mouth, thirst, drinking water, oral mucosa, ecchymosis, edema, swelling of the gums, pain in the teeth, or burning sensation in the mouth. (2) Weight and weight are slowly reduced, and there is no obvious cause. (3) Physical fatigue, often hunger, sweating, fatigue, palpitations, trembling, and low blood sugar. (4) Urine: Male urinary frequency, more urine. (5) There are yellow flat new creatures (yellow tumors) under the eyelids. (6) The skin lower limbs and foot ulcers are unhealed for a long time; or there are repeated skin and vulvar infections; skin abrasions or scratches are not easy to heal, or there are repeated balanitis, vulvitis, and vaginitis. (7) vascular arteriosclerosis, hypertension, coronary heart disease. (8) Reproductive women have multiple abortions, pregnancy poisoning, excessive amniotic fluid, or a large fetus. 2. Clinical symptoms of insulinoma: 1 paroxysmal hypoglycemia or coma, psychotic symptoms; 2 blood sugar at the time of attack is less than 2.78mmol / L; 3 after oral or intravenous glucose, the symptoms disappeared immediately. These three items are called Whipple triad or insulinoma triad. The symptoms of hypoglycemia are more frequent than in the morning, on an empty stomach, after exertion, or when the mood is tense. The interval varies from one day to several weeks or several months. However, not all patients have very typical symptoms, and some manifest as chronic hypoglycemia symptoms, such as personality changes, memory loss, gait instability, unclear vision, sometimes arrogance, hallucinations, abnormal behavior, and even misdiagnosed For mental illness. People who need to be examined: patients with abnormal insulin release such as diabetes and insulinoma. Low results may be diseases: high diabetes results may be diseases: type I diabetes, gestational diabetes, diabetes in the elderly, insulinoma precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process [method] 1, overnight fasting. 2, oral glucose 100 grams, before taking sugar, 0.5 hours, 1 hour, 2 hours, 3 hours after taking sugar, blood and insulin were taken. Insulin/blood sugar is the release index for each phase. [Result judgment] (1) The fasting plasma insulin concentration of normal people is 5-20mU/L, and reaches the highest peak 30-60 minutes after oral administration of 100g glucose, about 8-10 times the basic value, and returns to the original level after 3 hours. (2) The fasting plasma insulin concentration of type 1 diabetes was slightly lower than normal. The peak appeared at 90-120 minutes after oral administration of 100g glucose, but it was lower than normal. (3) The fasting plasma insulin concentration of obese patients with type 2 diabetes was higher than normal or normal, and reached the peak 2 hours after oral administration of 100g glucose, which was significantly higher than normal. (4) The fasting plasma insulin concentration of insulinoma patients is significantly increased, the physiological relationship between blood glucose concentrations is abnormal, and insulin is not properly secreted. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks No obvious complications and harms.