vasopressin test

The test of vasopressin is carried out by the following principle: the plasma osmotic pressure increases and the circulating blood volume decreases after the normal person bans water, both of which stimulate the release of ADH, increase the urine specific gravity, and increase the osmolality and blood. The osmotic pressure does not change much. Before the test, the body weight, blood pressure, blood osmotic pressure, urine osmotic pressure and urine specific gravity were measured. After that, urine was measured every hour, urine specific gravity and urine osmotic pressure were changed. The urine volume was not changed twice, and the urine osmotic pressure was <30 mosm. /kg, it shows that the endogenous ADH secretion has reached the maximum amount or the patient's weight loss is 3%-5%, or the patient has blood pressure drop, the blood osmotic pressure and urine osmotic pressure are measured at the time of psychiatric symptoms, and the subcutaneous injection of water is added. Pressure 5U, then urine test 1-2 times urine volume, urine osmotic pressure. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Tips: Check before taboo: pay attention to normal diet, pay attention to normal routine. Normal value Normal people and spiritual polydrinks have little change in body weight, blood pressure and blood osmotic pressure after drinking water, urine volume is gradually reduced, urine specific gravity is increased, more than 1.020, urine osmotic pressure is increased, more than 2 times higher than blood osmotic pressure. More than 750mosm / kg, after injection of water vasopressin, urine osmotic pressure can not further increase significantly (not more than 9%), and sometimes even decreased. Clinical significance This examination can identify pituitary diabetes insipidus and renal diabetes insipidus. After the urine volume, urine specific gravity and urinary osmotic pressure are stabilized, 5 units of pituitary vasopressin (0.1 unit/kg body weight) can be found in the patient. Although it is positive in the water-free test, the effect of pituitary diabetes insipidus is obvious. The urine volume decreased, the urine specific gravity and osmotic pressure increased, and the renal diabetes insipidus did not respond significantly. Abnormal results: The urine specific gravity of patients with diabetes insipidus decreased by >3% after the water was banned. In severe cases, the blood pressure decreased, and there were mental symptoms such as irritability. Partial diabetes insipidus has a slight increase in urine specific gravity after reaching the water, reaching 1.015. The urine osmotic pressure may slightly exceed the blood osmotic pressure, but often <600 mosm/kg, which is still lower than normal. The urine osmotic pressure can continue to rise after the injection of vasopressin (>10% increase, or increase value >800 mosm/kg). 2 The average blood osmotic pressure after complete water insipidus was >300mosm/kg, the urine volume was not significantly reduced, the urine specific gravity did not exceed 1.010, the urine osmotic pressure did not increase significantly, lower than the blood osmotic pressure, the injection of water added After the vasopressin, the amount of urine decreased, and the osmotic pressure of urine increased significantly, which was >50% or even doubled. 3 Renal diabetes insipidus can not be concentrated after the water is banned, and there is still no reaction after the injection of vasopressin. People who need to be examined: Patients suspected of having pituitary diabetes insipidus and renal diabetes insipidus can also determine which type of diabetes insipidus is a patient with diabetes insipidus. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process 【method】 Before the test, the body weight, blood pressure, blood osmotic pressure, urine osmotic pressure and urine specific gravity were measured. After that, urine was measured every hour, urine specific gravity and urine osmotic pressure were changed. The urine volume was not changed twice, and the urine osmotic pressure was <30 mosm. /kg, it shows that the endogenous ADH secretion has reached the maximum amount or the patient's weight loss is 3%-5%, or the patient has blood pressure drop, the blood osmotic pressure and urine osmotic pressure are measured at the time of psychiatric symptoms, and the subcutaneous injection of water is added. Pressure 5U, then urine test 1-2 times urine volume, urine osmotic pressure. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.