Atropine Inhibition GH Test

The atropine inhibition GH test is carried out on the principle that the cholinergic blocker atropine inhibits the action of acetylcholine in the arcuate nucleus and inhibits the release of GHRH, thereby reducing the secretion of pituitary GH. The secretion of GH from pituitary GH tumor is autonomic and is not inhibited by atropine. This test is helpful for the differential diagnosis of pituitary GH tumors. Basic Information Specialist classification: growth and development check classification: physical examination Applicable gender: whether men and women apply fasting: fasting Tips: Check before taboo: pay attention to normal diet, pay attention to normal work and rest, prevent endocrine disorders. Normal value GH levels can be suppressed to less than 3 ug/L after taking the drug in normal people. Clinical significance Patients with pituitary GH tumors were not inhibited, and GH levels after administration decreased by less than 50% of the control value. Abnormal results: 1. Pituitary GH tumor mainly manifests as giant disease, face changes, large hands and feet (wearing the size of the shoes increased), blood sugar is elevated. 2. Tumor enlargement can also cause headaches, dizziness, decreased vision, visual field defects (both sides can not see clearly) and other common performance. Also drink more urine (thirst, more urine). If it is a pituitary tumor (tumor bleeding), it can also have severe headache, nausea, vomiting, and even blindness. People in need of examination: Patients suspected of having pituitary GH tumors. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process [method]: 1. Fasting overnight and staying in bed. 2. Oral atropine 0.6mg. 3. Blood was measured at 0, 30, 60, and 90 min to measure GH. [Results] The patient's serum GH was high and there was no significant decrease after taking the drug, that is, it was not inhibited by atropine and supported pituitary GH tumor. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.