TRH excited TSH, PRL test

TRH Excited TSH, PRL test (thyroid stimulating hormone releasing hormone stimulation test) is to determine whether the subject to be examined has primary hypothyroidism, pituitary tumor patients, anterior pituitary dysfunction, hypothalamic lesions and other diseases of the anterior pituitary Functional inspection. [Principle] TRH is a small peptide composed of three amino acids of gluten, group and sputum. It has the dual roles of excitatory pituitary secretion of TSH and pituitary prolactin cells secreting PRL. A certain dose of exogenous TRH was injected to observe the secretion reaction of TRH and PRL, and the reserve function of pituitary TSH cells and PRL cells was evaluated. Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Check before taboo: pay attention to normal diet, pay attention to normal work and rest, prevent endocrine disorders. Normal value The normal person's TSH level is 0.3-5mIU/L, with an average of 1.3mIU/L. After TRH excitation, TSH and PRL rise to more than 3 times of the baseline value and the peak appears at 30MIN. Clinical significance 1. The baseline level of TSH in patients with primary hypothyroidism was significantly higher than that in normal subjects. The increase in TSH after TRH excitement was close to that of normal subjects, but the absolute value of elevation was significantly increased. 2. TSH in 40% of patients with pituitary tumors has reduced response to TRH excitability, or no response, but no clinical manifestations of hypothyroidism. 3. The degree of response in patients with anterior pituitary dysfunction is related to the degree of damage to TSH cells, which may be low or no response. 4. Hypothyroidism caused by hypothalamic lesions is mostly delayed, and the peak of the reaction appears at 60 or 90 minutes. The reason for the delayed response is that although the pituitary cells are intact, they are not excited by TRH and are in a functional resting state. 5. TSH in patients with endocrine exophthalmos may not respond to TRH excitability. Abnormal results: 1, 90% of patients with pituitary PRL adenoma increased basal levels, TRH excitatory response decreased. 2, various causes of anterior pituitary hypofunction can reduce the response. 3, simple hyperprolactinemia TRH stimulation test reaction is generally normal, a small number of reactions are reduced. The people who need to be examined are: primary hypothyroidism, pituitary tumor patients, anterior pituitary dysfunction, hypothalamic lesions and other suspected symptoms. High results may be diseases: children without thyroid cretinism, resting lymphocytic thyroiditis, acromegaly, iodine-induced hyperthyroidism, hyperprolactinemia precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process [Principle] TRH is a small peptide composed of three amino acids of gluten, group and sputum. It has the dual roles of excitatory pituitary secretion of TSH and pituitary prolactin cells secreting PRL. A certain dose of exogenous TRH was injected to observe the secretion reaction of TRH and PRL, and the reserve function of pituitary TSH cells and PRL cells was evaluated. [method] 1. Subjects do not need special preparation. 2. Dissolve TRH200ug in 2ml normal saline and make a rapid intravenous bolus. 3. Blood samples were taken from the forearm at 0, 30, 60, and 90 min, and serum was separated for TSH. Analysis of results: The patient's test results showed that TSH increased to nearly 3 times the baseline value after excitation, suggesting that the pituitary-thyroid axis reserve function is acceptable; PRL is not significantly increased after excitation, suggesting that the pituitary-gonadal axis reserve function is poor. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.