GnRH stimulation test

The GnRH stimulation test is a gonadotropin-releasing hormone (GnRH) stimulation test that is used to test the function of the pituitary and ovary. LHRH (Luteinizing Hormone Releasing Hormone) has an excitatory effect on pituitary gonadotropin. Peripheral blood is taken at different time points after injection of exogenous LHRH. The gonadotropin content can be measured to understand pituitary function. If the function of the pituitary is good, the level of gonadotropin is increased, and vice versa, the reactivity is poor. Basic Information Specialist classification: neurological examination classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Normal value 1. The peak of the reflection of normal adult male LH is more than 5 times higher than the basic, and the peak value appears in 30-60 minutes. 2. The reflection of normal adult female LH varies with different stages of the menstrual cycle. 3, pre-puberty children showed a weak response, the peak value was less than 3 times higher than the baseline value. Clinical significance Abnormal results: 1 hypothalamic dysfunction, low FSH, LH base value, GnRH excitation test showed normal reaction; 2 pituitary dysfunction, FSH, LH base is low, GnRH stimulation test showed no response or weak response, seen in surgery or radiation damage pituitary tissue and Xihan syndrome; 3 ovarian insufficiency, FSH, LH base value is high, GnRH excitation test is active; 4 Polycystic ovary syndrome, FSH base value is normal or low, LH base value is higher, GnRH stimulation test LH is active, and FSH is normal. The people who need to be examined are: suspected hypothalamic dysfunction, pituitary dysfunction, ovarian insufficiency, polycystic ovary syndrome and other symptoms. Precautions Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process The GnRH stimulation test, also called the pituitary stimulation test, is a test used to examine the function of the pituitary and ovary. Usually in the morning, fasting, GnRH100mg one-time intravenous injection, before and after treatment, 30, 60, 90 minutes after the venous blood test serum FSH and LH, 30-90 minutes after administration, 3 times before the administration of the drug and FSH is not Change, suggesting that the pituitary function is good; LH no response, suggesting that the pituitary dysfunction; if both FSH and LH reactions are hyperthyroidism or FSH response than LH hyperthyroidism, suggesting that the problem is not in the pituitary, is the ovarian function decline. Not suitable for the crowd Inappropriate population: Subjects fasted overnight, stayed in bed during the trial, and did not smoke. Adverse reactions and risks There are no related complications and hazards.