c-peptide release assay

The c-peptide release test was carried out by the following principle. The C peptide is a secreted product of islet beta cells, which shares a common precursor with insulin, proinsulin. A molecule of proinsulin is cleavage into one molecule of insulin and one molecule of C-peptide under special action. Therefore, in theory, C-peptide and insulin are secreted equally, and the physiological function of free C-peptide in blood is not clear. However, the C peptide is not destroyed by the liver, and the half-life is significantly longer than that of insulin. Therefore, the determination of the C-peptide level is more responsive to the synthesis and release of insulin by the β-cell. Basic Information Specialist classification: growth and development check classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to the normal diet before the examination, pay attention to normal work and rest, and prevent endocrine disorders. Normal value The amount of secretion is normal. Clinical significance Abnormal results: (1) Determination of C peptide, which contributes to the clinical classification of diabetes and helps to understand the islet function of patients. (2) Since the C-peptide is not interfered with by the insulin antibody, the C-peptide concentration can be directly measured for the patient receiving insulin treatment to determine the patient's islet β-cell function. (3) The cause of hypoglycemia can be identified. If the C peptide exceeds normal, it can be considered to be caused by excessive insulin secretion. If the C peptide is lower than normal, it is caused by other reasons. (4) C-peptide determination is helpful for the diagnosis of islet cell tumor and the effect of insulinoma surgery. The level of C-peptide in insulin is high. If the level of C-peptide in blood is still high after surgery, there is residual tumor tissue. The level of C-peptide increased during follow-up, revealing the possibility of tumor recurrence or metastasis. People who need to be examined: diabetes, islet cell tumor, islet β-cell dysfunction and other related diseases. High results may be diseases: precautions for diabetes in the elderly and gestational diabetes Forbidden before examination: pay attention to normal diet, pay attention to normal work and rest, and prevent endocrine disorders. Requirements for inspection: Actively cooperate with the doctor's request. Inspection process There is a fairly stable proportional relationship between C-peptide and insulin, and it is not interfered by insulin antibody. The injected exogenous insulin does not contain C-peptide. Therefore, the level of C-peptide in blood can be measured to reflect the level of endogenous insulin. Can understand the function of beta cells. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.