Serum aspartase aminotransferase isoenzyme

AST has two isozymes, m-AsT present in hepatic cytoplasmic s-AST and hepatocyte mitochondria. s-AST is easily released into the blood, m-AST is tightly bound to the sub-structure of the cell and is difficult to release into the blood, so the serum s-AST accounts for 60% to 80%. In the case of mild to moderate hepatocyte damage, only soluble enzymes are released from the liver cytoplasm; if the liver cells are damaged or even necrotic, the enzymes in the mitochondria are also released. m-AST was used as an indicator of severe liver damage and hepatocyte necrosis. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value m-AST 2.8 ~ 6.2 U / L (inhibition method 37 ° C); m-AST accounts for 9.0% to 16.5% of AST (electrophoresis method). Clinical significance Elevated in viral hepatitis, chronic hepatitis, active cirrhosis, myocardial infarction, cardiomyopathy. High results may be diseases: aspartyl glucosamine, myocardial infarction, cirrhosis, cardiomyopathy, viral hepatitis, chronic hepatitis Note before the inspection: fasting for more than 12 hours. Inspection process 2 ml of fasting venous blood was taken and placed in a dry tube for examination to avoid hemolysis of the specimen. Continuous monitoring method for testing. Not suitable for the crowd Generally no taboos. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.