Non-Treponema pallidum antigen serum test

The non-treponema pallidum antigen serum test is a test for measuring anti-cardiolipin antibodies in serum using cardiolipin as an antigen. The test is highly sensitive and low in specificity, and is prone to biological false positives. After adequate treatment of patients with early syphilis, the responsiveness can disappear, and the early untreated patients can be reduced or disappeared in some patients. Basic Information Specialist classification: Infectious disease examination and classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: Negative: 1:40 or less - Positive: greater than 1:40- Above normal: negative: normal. Positive: Infected with syphilis. Tips: Pay attention to normal eating habits and pay attention to personal hygiene. Prohibition of unclean sexual intercourse. Normal value The test was negative and normal, and the Treponema pallidum specific antibody (TPHA) was negative below 1:40. Clinical significance Non-treponema pallidum antigen serum tests are currently generally used as screening and quantitative tests to observe efficacy, recurrence and reinfection. Abnormal results The abnormal results of syphilis in different periods are different: 1 stage syphilis: that is, hard chancre, incubation period of 2 to 4 weeks, dark red hard mass, shallow ulcer, external cartilage, cartilage-like hardness, peripheral lymph nodes. 2 secondary syphilis: After 1 to 2 months of syphilis in the first stage, the skin and mucous membranes of the whole body are symmetrically rash, rash, papules, pustules, etc. Mucosal plaques, flat wet phlegm can occur in the mucosa, and the infection is strong. 3rd stage syphilis: occurs 2 to 3 years or even 10 years after infection, the skin is a gum-like swelling, and may also involve bone, joint, heart, blood vessels, manifesting aortic inflammation, aortic insufficiency and aortic aneurysm, etc. Invading the nerves for spinal cord spasm, generalized paralysis (paralytic dementia). Congenital syphilis has early congenital syphilis, equivalent to the second day of the day, but heavier. Late congenital syphilis is similar to the acquired day, but few heart, blood vessel and neuropathy occur. Mainly for substantial keratitis, neurological deafness, Hutchinson's teeth (central incisors in the upper incisors, small upper and upper, equal width and width), sabre-shaped humerus and so on. There may be latent syphilis between stages, asymptomatic, and only seropositive. The treatment uses penicillin or erythromycin, tetracycline, and the like. The people who need to be examined are: the above-mentioned patients with syphilis symptoms such as hard chancre, rash, pimples, pustular rash, neurological deafness, and Hutchinson's teeth. Positive results may be diseases: syphilitic cardiovascular disease, non-sexual syphilis, syphilitic heart disease in the elderly Forbidden before examination: Pay attention to normal eating habits and pay attention to personal hygiene. Prohibition of unclean sexual intercourse. Requirements for inspection: Actively cooperate with the doctor. Inspection process 1. Venereal Disease Research Laboratory test (VDRL); using cardiolipin, lecithin and cholesterol as antigens, can be used for quantitative and qualitative tests, reagents and control serum have been standardized, low cost. This method is commonly used, the operation is simple, and the result needs to be read by a microscope. The disadvantage is that the sensitivity of the first stage syphilis is not high. 2. Rapid Plasma Responsive Test (RPR): It is an improvement of VDRL antigen, and its sensitivity and specificity are similar to those of VDRL. The advantage is that the result can be read by the naked eye. 3. Unheated Serum Reagin USR is also an improvement of VDRL antigen with similar sensitivity and specificity to VDRL. Not suitable for the crowd Inappropriate crowd: temporarily unknown. Adverse reactions and risks There are no related complications and hazards.