Interleukin 5 (iL-5)

Interleukin (il-5) is also produced by antigen-activated cd4+t cells; mast cells can also produce il-5. Natural il-5 has a molecular weight of 40 to 50 kd and is a dimeric glycoprotein linked by disulfide bonds, but monomer il-5 also has il-5 activity. Il-5 has been supplemented by tcellreplacing factor (trf), and it has been found that human il-5 has no obvious stimulating effect on b cells; its main function is to stimulate eosinophil proliferation, differentiation and activation. Il-5 not only increases the number of eosinophils, but also enhances its function. Eosinophilia in worm infections and allergic diseases is mainly caused by il-5. Human il-5 also promotes the release of inflammatory mediators such as histamine and leukotrienes from basophils, thereby increasing the activity of basophils. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Tips: Avoid testing after strenuous exercise. Normal value Radioimmunoassay: serum is 56.37 ~ 150.33 picogram / ml. Clinical significance Abnormal results: (1) Increase: seen in body damage, inflammation, rheumatoid arthritis, multiple myeloma, systemic lupus erythematosus, hepatitis, burns and kidney transplant rejection. In patients with digestive tract malignancies, serum IL-5 is elevated and decreased after surgery. (2) Determination of blood, urine and local tissue fluid IL-5, which has important effects on the identification of rejection, monitoring rejection and therapeutic evaluation of organ transplantation; in acute rejection, IL-5 in body fluids is significantly increased, and the treatment is effective and rapid. Decreased, IL-5 continued to rise in patients with ineffective treatment. People who need to be examined: Inflammatory or infectious diseases such as patients with allergic diseases can be examined. High results may be diseases: precautions for blackening after inflammation Contraindications before examination: pay attention to diet, and avoid detection after strenuous exercise. Requirements for inspection: The conditions and requirements for the measurement shall be strictly in accordance with the regulations. Avoid sample lighting. Avoid detection after strenuous exercise. Inspection process The ELISA method was used to detect the content of interleukin 5 after sampling. Not suitable for the crowd Inappropriate crowd: generally not. Adverse reactions and risks There are no related complications and hazards.