Interleukin 4 (iL-4)

Interleukin (il-4) is produced by antigen or mitogen-stimulated cd4+t cells, and activated mast cells can also produce il-4. The human il-4 gene, like il-3 and il-5, is located on chromosome 5. The mature il-4 has a molecular weight of 18 to 19 kd. The biological activity of il-4 includes the proliferation of b cells that promote antigen or mitogen activation; promotes the activity of tc cells; il-4 does not stimulate macrophage proliferation, but enhances macrophage function; il-4 and The synergistic effect of il-3 can maintain and promote the proliferation of mast cells, which has certain significance in the occurrence of certain allergic diseases; it can synergize with csf to promote the proliferation of bone marrow hematopoietic precursor cells and induce the differentiation of myeloid cells; Induction of endothelial cells to express vascular cell adhesion molecule-1 (vcam-1) has a certain significance for lymphocyte migration. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Tips: Avoid testing after strenuous exercise. Normal value There is no uniform normal value due to different measurement methods. Clinical significance Abnormal results: IL-4 is the most clinically involved anti-tumor therapeutic effect. IL-4 receptor is known to be expressed on a considerable number of tumor cells, including lymphoblastic leukemia, multiple myeloma, non-Hodgkin Disease, acute promyelocytic leukemia and certain solid tumors. Clinically, IL-4 has a certain effect in the treatment of Hodgkin's disease, non-Hodgkin's disease, and chronic lymphocytic leukemia. People who need to be examined: mainly patients with cancer and related diseases need to be examined. Precautions Contraindications before examination: pay attention to diet, and avoid detection after strenuous exercise. Requirements for inspection: The conditions and requirements for the measurement shall be strictly in accordance with the regulations. Avoid sample lighting. Inspection process The ELISA method was used to detect the content of interleukin 4 after sampling. Not suitable for the crowd Inappropriate crowd: generally not. Adverse reactions and risks There are no related complications and hazards.