lidocaine metabolism test

Lidocaine metabolism test is a quantitative test of liver function mainly reflecting liver metabolism. Lidocaine is mainly metabolized in the liver and metabolized rapidly. About 90% of the cells are dealkylated by hepatic cytochrome P-450 system to produce monoethylglycine. Xylidine (MEGX) is mainly excreted by the kidneys. The rate of lidocaine clearance in healthy people depends mainly on hepatic blood flow. The MEGX test reflects the viability of hepatic cytochrome P-450. Patients with liver disease have a slower metabolic rate, and the MEGX test directly reflects the function of liver cells. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: not fasting Tips: You must not drink alcohol the day before. Pay attention to ensure adequate sleep before the examination, do not exercise vigorously. Normal value The normal human lidocaine concentration was 0.83±0.45 μg/ml, and the MEGX concentration was 127.25±26.25 ng/ml. Clinical significance Abnormal results The average MEGX concentration of patients with cirrhosis for 60 min was 58.25±33.39 ng/ml. Need to check patients with cirrhosis in the population. Precautions Taboo before inspection 1. Be careful not to take the drug before the test, because some drugs will increase the burden on the liver, causing temporary damage to the liver function, which will lead to the accuracy of the liver function test results. 2. Pay attention to ensure adequate sleep before exercise, do not exercise vigorously, which may cause elevated transaminase, thus affecting the test results. 3. You must not drink alcohol the day before. Drinking alcohol will cause an increase in transaminase and affect the test results. 4. Prepare the solution of lidocaine before the test, pay attention to adjust the pH. Contraindications during the examination: pay attention to the interval between blood collection. Inspection process 1. Administration: The subject was intravenously injected with lidocaine hydrochloride 1 mg/kg. 2. Blood collection: 1.5 ml of venous blood was collected at 0, 3, 6, 10, 15, 30, 45, 60, 90, 120, 300 min after administration, and serum was prepared to determine the concentration of lidocaine and its metabolite MEGX. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.