Liver fibrosis index test

Hepatic fibrosis indicators were examined with PCIII (type III procollagen), IV-C (type IV collagen), LN (laminin), HA (hyaluronidase), CG (glycine), PLD (proline). Peptidase), MAO (monoamine oxidase), PINP (type I procollagen amino terminal propeptide). The liver fibrosis index test is an assessment of the degree of liver fibrosis in chronic liver disease. Early detection of liver fibrosis is conducive to curbing the progress of hepatitis B in a worse direction. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: fasting Tips: Do not take medication before the examination, because some drugs will increase the burden on the liver, causing temporary damage to liver function, resulting in the accuracy of liver function test results. Normal value 1. PCIII (type III procollagen) normal range <18 ng / mL. 2. IV-C (type IV collagen) normal range 30-140 ng / mL. 3. LN (laminin) normal range of 50-180 ng / mL. 4. HA (hyaluronanase) normal range <120ng/mL. 5. The normal value of purine peptidase (PLD) is 1107±19.5u/L. 6. The normal value of monoamine oxidase (MAO) is 3.3-15.1 nmol/(s·L). Clinical significance Abnormal result 1. Slow live liver with continuous pciii, suggesting that the condition may worsen and develop into cirrhosis. 2. The increase of IV-C (type IV collagen) can reflect the degree of liver fibrosis. With the slow migration of liver → slow live liver → liver cirrhosis → liver cancer disease course, IV-C collagen gradually increased in serum. 3. The higher the LN level, the more significant the esophageal varices in patients with cirrhosis. 4. Blood HA is higher than 100 μg / L, indicating the presence of cirrhosis and liver fibrosis. 5. CG in patients with acute hepatitis, chronic active hepatitis, cirrhosis and primary liver cancer were significantly higher than those in the normal control group. 6. Chronic hepatitis and cirrhosis in quiescent period, ALT is normal, and PLD is significantly elevated. Therefore, PLD is a good indicator of acute liver damage and progressive liver fibrosis. 7. Increased MAO in patients with liver cancer indicates that the patient is accompanied by cirrhosis. 8. The amount of synthesis increases during liver fibrosis, causing a change in the concentration of PINP in the serum. Need to check patients with liver fibrosis, cirrhosis patients. High results may be diseases: liver cirrhosis, liver fibrosis considerations Taboo before inspection: 1. Be careful not to take the drug before the test, because some drugs will increase the burden on the liver, causing temporary damage to the liver function, which will lead to the accuracy of the liver function test results. 2. Pay attention to ensure adequate sleep before exercise, do not exercise vigorously, which may cause elevated transaminase, thus affecting the test results. 3. You must not drink alcohol the day before. Drinking alcohol will cause an increase in transaminase and affect the test results. 4. Accept the patient's consent when undergoing a liver biopsy. Taboo when checking: 1. Can not eat before the examination, blood test requires fasting, fasting time is generally 8 to 12 hours. 2. Take care when performing a liver biopsy, do not hurt the patient. 3. Because a single indicator can only reflect one aspect of liver fibrosis production and degradation and because connective tissue is susceptible to systemic metabolism. Therefore, combined detection of several indicators can achieve satisfactory sensitivity and specificity. Inspection process 6 ml of venous blood was drawn, and CIII (type III procollagen), IV-C (type IV collagen), LN (laminin), HA (hyaluronanase), CG (glycylate), were examined with ordinary tubes. PLD (proline peptidase), MAO (monoamine oxidase), PINP (type I procollagen amino terminal propeptide) concentration values. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., because the drug has certain damage to the liver, may affect the results of the examination, and it is forbidden to check patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.