Aminopyrine breath test

The aminopyrine breath test is the most used liver function breath test, mainly used in the diagnosis and identification of liver disease, prognosis of liver cirrhosis, risk prediction of surgical intervention and liver function monitoring. Compared with other liver function tests, it has Simple, safe, accurate and non-invasive. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: not fasting Tips: Pregnant women, lactating women should not do this test. Those who use antibiotics, sputum preparations, and proton pump inhibitors within one month should not be treated with acute gastric bleeding within five days. Normal value The normal range of ABT values ​​is between 5-10%. Clinical significance Abnormal results ABT values ​​were reduced in hepatitis, cirrhosis, alcoholic liver disease, fatty liver and liver cancer, and early ABT values ​​were normal in primary biliary cirrhosis. Need to check patients with impaired liver function. Low results may be diseases: liver cirrhosis, liver cancer considerations Taboo before inspection: 1. After an early morning fasting or eating for two hours. 2. The CO2 gas-gathering agent should not be opened before use to avoid affecting the measurement results by absorbing CO2 in the air. Taboo when checking: 1. If there is a small amount of inhalation in the test solution, spit it out immediately and rinse with water. 2. If the test solution is spilled onto sensitive parts such as the eyes, rinse immediately with plenty of water. Inspection process (1) After oral administration of 14C-aminopyrine (0.5-2mCi), the subject will be inhaled into the liquid flash bottle (seaamine 2mL, ethanol 2mL) at 30-120min. When 2mmoL CO2 and sea amine are completely When the reaction pH is less than 9, the indicator thymolphthalein changes from blue to colorless. (2) The radioactivity count of 14CO2 per mmoLCO2 was determined. (3) An average of 9 mmoL of endogenous CO2 was produced per kilogram of body weight per hour, and a radioactive count of exhaled breath for a total of 2 hours (or other time periods) was calculated. (4) Find the cumulative 2h (or other time period) exhaled air radioactivity count as a percentage of the given amount. Not suitable for the crowd 1. Pregnant women and lactating women should not do this test, which may affect the fetus. 2. Those who use antibiotics, sputum preparations, and proton pump inhibitors within one month should not be tested for acute gastric bleeding within five days. Adverse reactions and risks Risk of poisoning: If the subject is intolerant to the test reagent or inhaled too much, it may be poisoned, and anaphylactic shock may occur, manifested as chest tightness, dizziness, nausea and vomiting, decreased blood pressure, and sweating.