tissue factor pathway inhibitor

Tissue factor pathway inhibitor (TFPI) is an in vivo natural anticoagulant protein that controls the initiation phase of coagulation. It has a specific inhibitory effect on the tissue factor pathway (ie, the exogenous coagulation pathway). It has been called extrinsic pathway inhibition. Things. Because TFPI in plasma is mostly present in the lipoprotein fraction, it was previously called lipoprotein-associated coagulation inhibitor. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before, and avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should fast. Normal value TFPI binds to low density lipoprotein (LDL). 5% to 10% of full-length TFPI is in a free state. Clinical significance Abnormal result It was found that elevated levels of TFPI were also elevated in atherosclerosis, which occurred simultaneously with TF in endothelial cells in plaque areas, macrophages and smooth muscle cells surrounding necrotic areas. Hypercoagulable state and inflammatory reaction are the two major pathological features of infectious diseases, which often lead to the deterioration of the disease and even cause multi-functional organ failure, which directly threatens the life of the patient. Therefore, anticoagulant and anti-inflammatory are increasingly treated in the treatment of serious infectious diseases. The more people are valued. Animal experiments have found that TFPI can significantly improve the symptoms of severely infected animals and increase their survival rate. The people who need to be examined have red, swollen, hot, painful and dysfunctional and heart pain. High results may be diseases: sepsis, thrombosis considerations Taboo before the test: Do not eat too greasy, high-protein foods the day before the test, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should fast. Requirements for examination: When taking blood, you should relax your mind to avoid the contraction of blood vessels caused by fear and increase the difficulty of blood collection. Inspection process The recombinant protein of TFPI was purified by chromatography, and the recombinant protein was labeled with 125I. The pulsed injection was used to compare the plasma metabolic clearance rate of the four rats in SD rats. The recombinant protein was used to inhibit the activity of factor Xa (Fxa) by substrate chromogenic assay. The inhibitory effect of TFPI recombinant protein mutant on FXa in vitro and in vivo and the effect of heparin on the function of TFPI recombinant protein were compared. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.