Plasma tissue plasminogen assay

Plasma tissue plasminogen assay is a measure of plasma plasminogen and is useful for determining fibrinolytic system activity. It includes detection of plasma tissue plasminogen activator activity (t--PAA), detection of plasma tissue plasminogen activator antigen (t--PAAg), plasma tissue plasminogen activator inhibitor activity Detection, detection of plasma tissue plasminogen activator inhibitor antigen, plasma plasmin-anti-plasmin complex assay (PAP). Detection of plasma tissue plasminogen is helpful in determining the activity of the fibrinolytic system. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before, and avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should fast. Normal value Detection of plasma tissue plasminogen activator activity 19--2.61 U/ml. Detection of plasma tissue plasminogen activator antigen 1--12 μg / L. Detection of plasma tissue plasminogen activator inhibitor activity 0.1 to 1.0 inhibition unit/ml. Detection of plasma tissue plasminogen activator inhibitor antigen 0.3 IU/ml. Plasma plasmin-anti-plasmin complex assay detects 0.8 to 1.2 inhibition units/ml. Clinical significance Abnormal result Detection of plasma tissue plasminogen activator activity (t--PAA): Pathological increase or decrease indicates an increase or decrease in the ability to activate plasminogen, and an increase or decrease in fibrinolytic system activity. Detection of plasma tissue plasminogen activator antigen (t--PAAg). Detection of plasma tissue plasminogen activator inhibitor activity: plasma plasminogen activator inhibitor activity gradually increased, and the pregnancy-induced hypertension increased gradually. Detection of plasma tissue plasminogen activator inhibitor antigen: Increase or decrease in plasma activator inhibitor antigen indicates impaired fibrinolytic activity or fibrinolytic activity. Plasma plasmin-anti-plasmin complex assay (PAP): Parallel PAP in the blood can affect the patients with diabetes and its chronic complications through thrombosis and hemostasis. People who need to be examined: middle-aged and elderly people, with limb pain, swelling, superficial venous engorgement and cords that can be touched along the vein. Low results may be diseases: thrombosis considerations Inappropriate crowd: pregnant women, newborns. Taboo before the test: Do not eat too greasy, high-protein foods the day before the test, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should fast. Requirements for examination: When taking blood, you should relax your mind to avoid the contraction of blood vessels caused by fear and increase the difficulty of blood collection. Inspection process The chromogenic substrate method: the test plasma is added with streptokinase (SK) and the chromogenic substrate (S-2251), and the PLG in the test plasma is converted into PL under the action of SK, and the latter acts on the chromophore. The substance releases p-nitroaniline (PNA) and develops color. The depth of color development was positively correlated with the level of plasmin, and the content of PLG:A in plasma was calculated by calculation. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.