Bronchial Provocation Test (BPT)

The bronchial provocation test uses different excitons to induce abnormal bronchial contractions. The degree of high reactivity of the airway can also be judged by the quantitative measurement of the irritant and the corresponding degree of reaction. Inhaled bronchial provocation test is the most common method used in clinical and experimental methods, including various inhaled non-specific excitons, such as histamine, methacholine, acetylcholine, adenosine, leukotriene E4, hypertonic saline, hypotonic Salt water, cold air inhalation, and specific antigen stimuli such as dust mites, pollen, and animal skin. Basic Information Specialist classification: Respiratory examination classification: pulmonary function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Tips for asthma. Tips: Maintain a normal diet and schedule. Normal value Promoting concentration of normal adult histamine PC20FEV1 ≥ 8 mg / ml or inhaled acetylcholine accumulation (Provokingdose) PD20FEV1 ≥ 12.8 μmol. Clinical significance Clinical use: 1 for airway reactivity testing to identify or exclude bronchial asthma. 2 to observe the development of asthma and treatment effects. 3 Epidemiological studies of asthma. Clinical significance: (1) The cumulative amount of acetylcholine is less than 12.8 μmol or PC40FEV <8 mg/ml is positive for bronchial provocation test. (2) PC20FEV1<8mg/m1 or PD20FEV1<12.8μmol, suggesting bronchial hyperresponsiveness (BHR), combined with clinical diagnosis of bronchial asthma. Positive results may be diseases: pollen allergic asthma, cough asthma, occupational asthma considerations (1) The bronchial provocation test should be performed during the asthma remission period, and the basic FEV1/FVC ≥ 70% before the test. (2) Before the test, the bronchodilator was stopped for 12h, the antihistamine was used for 24h, the glucocorticoid was orally discontinued for 24h, and the inhalation was stopped for 12h. (3) When performing bronchial provocation tests, an experienced doctor should be present and equipped with treatment and monitoring equipment such as oxygen and bronchodilators. (4) The test is carried out under electrocardiogram and blood pressure monitoring. If dizziness, pale or cyanosis, angina pectoris, arrhythmia, ST segment progressive decline, and blood pressure rises or falls significantly, the exercise should be stopped immediately. (5) For patients with positive test, bronchodilator should be given until the induced bronchospasm is relieved. (6) banned from heart disease, high blood pressure, severe arrhythmia, severe cardiac insufficiency; severe pulmonary insufficiency, such as FEV1 <1.2L; hyperthyroidism; pregnancy. Inspection process The atomized liquid is sequentially inhaled from a low concentration to a high concentration by a quantitative atomizer inhaler (Dosimeter), and each inhalation is slowly inhaled from the residual gas position (or functional residual gas position) to the lung total amount in the inhalation. At the beginning, the aerosolized drug is ejected (the inspiratory flow rate is currently triggered to trigger the simultaneous ejection of the aerosolized drug). Each inhalation time is approximately 0.6 seconds for adults. Inhaled 5 times for each concentration. Pulmonary function was measured 3 minutes after inhalation. Then multiply the concentration inhalation. Not suitable for the crowd 1, heart disease, high blood pressure, severe arrhythmia, severe heart failure. 2, severe pulmonary insufficiency, hyperthyroidism, pregnancy. 3, respiratory infections or decreased lung function significantly do not do this check. Adverse reactions and risks It generally does not cause complications and harm.