Platelet lifespan

Platelet survival time (PLS): Thromboxane B2 (TXB2) is one of the major products of platelet arachidonic acid metabolic pathway epoxidase. Aspirin irreversibly inhibits platelet epoxidase until bone marrow megakaryocytes produce new platelets. Therefore, observing the recovery of platelet TXB2 after taking aspirin, the survival time of platelets can be inferred. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Reminder: The platelet count must be the same for each measurement, otherwise it will affect the measurement results. Normal value The PLS was 10.8 ± 4.2 days. Clinical significance Platelet survival time is shortened in: 1 platelet destruction increased diseases, such as primary thrombocytopenic purpura, drug-induced thrombocytopenic purpura, post-transfusion purpura, hypersplenism and systemic lupus erythematosus. 2 platelet hyperremediation diseases, such as DIC, thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. 3 hypercoagulable state and thromboembolic diseases, such as myocardial infarction, angina pectoris, diabetes with vascular disease, hyperlipidemia, major surgery, cerebrovascular disease, malignant tumor, deep vein thrombosis, pulmonary embolism, heart valve repair and Coronary artery transplantation and pregnancy-induced hypertension syndrome. 4 as an indicator of the efficacy of antiplatelet drugs. Low results may be diseases: pediatric thrombocytopenia, immune thrombocytopenic purpura in the elderly, congestive splenomegaly, idiopathic thrombocytopenic purpura, primary thrombocytopenic purpura, essential thrombocytosis, Presupposition of polycythemia (1) The blood sampling tube and the syringe must be silicified. (2) The platelet count must be the same for each measurement, otherwise the measurement results will be affected. (3) The sensitivity of this method is low when the number of platelets is too low. Inspection process Subjects were venously collected and assayed in time for serum separation. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.