Serum transferrin (Tf)

Transferrin (transferrin), also known as transferrin, is mainly produced by the liver and is a glycoprotein. It has two iron ion binding sites, and each binding site can bind to one iron ion. It is a β-globulin that binds to and transports iron in serum. Transferrin is mainly synthesized in the liver, and its reduction can be used as an indicator to judge the prognosis of liver disease. Through the measurement of serum transferrin, it can also respond to various diseases such as iron deficiency anemia. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Women in the late pregnancy, oral contraceptives, transferrin can be elevated. Normal value The normal value of transferrin in serum is 2.5-4.3 g/L. Clinical significance 1, lower Found in severe liver disease, malnutrition, diarrhea, nephrotic syndrome, infection, hemolytic anemia. 2, rise (1) Women who are seen in late pregnancy and oral contraceptives. (2) seen in repeated bleeding, iron deficiency, iron deficiency anemia. Low results may be diseases: pediatric protein-energy malnutrition, aplastic anemia high results may be diseases: iron deficiency anemia considerations 1, women in the late pregnancy, oral contraceptives, transferrin can be elevated. 2. Reference value of adult urine transferrin determination: 0.68mg/24h. Increased levels of urinary transferrin are mainly seen in diabetic nephropathy. Inspection process The serum to be tested was diluted 100 times with physiological saline, mixed, and allowed to stand at room temperature for 30 min. The excitation light and the scattered light were both 450 nm, and the fluorescence was corrected to zero by diluting the blank tube. The fluorescence readings of each tube were read separately. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness.