Serum - Nitric Oxide

Nitric oxide is a vasoactive substance released in recent years by vascular endothelial cells, epithelial cells, neutrophils, macrophages, platelets, and some nerve cells. Low concentrations of nitric oxide can relax bronchial smooth muscle and pulmonary vasodilation. High concentrations of nitric oxide have airway epithelial toxicity. There may be functional defects in NOS (nitric oxide synthase) in patients with bronchial asthma. And bronchial asthma is a chronic allergic inflammation involving a variety of inflammatory cells, induced by inflammatory cells, tumor necrosis factor alpha (TNF-α), interleukin I (IL-1) and endotoxin. Inducible NO synthase (iNOS) in epithelial cells and macrophages is activated, producing a large amount of NO. Excessive NO production leads to increased venule effusion of capillaries, DNA deamination, bronchial epithelial shedding and functional degeneration, which increases the inflammatory response, increases airway responsiveness, and exacerbates asthma symptoms. Basic Information Specialist classification: Oncology examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value (39 ± 11) μmol / L (nitrate ion NO2- / NO3-). Clinical significance (1) The content of NO in exhaled breath was 3 to 4 times higher than that in normal asthma, and NO2-/NO3- in plasma also increased. (2) There may be functional defects in NOS (nitric oxide synthase) in patients with bronchial asthma. And bronchial asthma is a chronic allergic inflammation involving a variety of inflammatory cells, induced by inflammatory cells, tumor necrosis factor alpha (TNF-α), interleukin I (IL-1) and endotoxin. Inducible NO synthase (iNOS) in epithelial cells and macrophages is activated, producing a large amount of NO. Excessive NO production leads to increased venule effusion of capillaries, DNA deamination, bronchial epithelial shedding and functional degeneration, which increases the inflammatory response, increases airway responsiveness, and exacerbates asthma symptoms. (3) Due to the biphasic effect of nitric oxide, it may have important research value in the pathogenesis and treatment of asthma. High results may be diseases: senile asthma, persistent state of asthma, precautions for asthma in children Recent studies have shown that endogenous nitric oxide proves that NO has both the performance of second messenger and neurotransmitter in physiological, neurological and immunological disciplines, and is the effector molecule of tumor cells, participating in tumors and inhibiting tumors. The aspects are closely related. Inspection process Subjects were venously collected and assayed in time for serum separation. Then it was determined by immunoturbidimetry. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness.